Ronconi Vanessa, Turchi Federica, Bujalska Iwona J, Giacchetti Gilberta, Boscaro Marco
Division of Endocrinology, Università Politecnica delle Marche, 60020 Ancona, Italy.
Trends Endocrinol Metab. 2008 Apr;19(3):100-3. doi: 10.1016/j.tem.2008.01.004. Epub 2008 Mar 4.
The central role of adipose tissue in the development of cardiovascular and metabolic pathology has been highlighted by the discovery of mediators (adipokines) secreted by adipose tissue and their involvement in the regulation of various biological processes. In light of recent experimental data, cross-talk between adipose tissue and the adrenal gland, particularly via the mineralocorticoid aldosterone, has been proposed. Aldosterone can induce adipogenesis, and human white adipose tissue is reported to release as-yet-uncharacterized factors that stimulate adrenocortical steroidogenesis and aldosterone production. These data could provide new insights into the pathophysiology of obesity-related disorders, including hypertension and aldosterone excess, with further studies necessary for confirming and better defining such adipose-adrenal interactions.
脂肪组织分泌的介质（脂肪因子）及其参与各种生物过程的调节，这一发现凸显了脂肪组织在心血管和代谢病理学发展中的核心作用。根据最近的实验数据，有人提出脂肪组织与肾上腺之间存在相互作用，特别是通过盐皮质激素醛固酮介导。醛固酮可诱导脂肪生成，据报道，人类白色脂肪组织会释放一些尚未明确的因子，这些因子可刺激肾上腺皮质类固醇生成和醛固酮产生。这些数据可能为肥胖相关疾病（包括高血压和醛固酮增多症）的病理生理学提供新的见解，还需要进一步研究来证实并更好地界定这种脂肪 - 肾上腺相互作用。
