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兰索拉唑的新型作用位点通过放射自显影揭示：与幽门螺杆菌、结肠、食管等的关系。

Lansoprazole Novel Effector Sites Revealed by Autoradiography: Relation to Helicobacter pylori, Colon, Esophagus and Others.

机构信息

School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Mitato-ku, Tokyo 108-8641, Japan.

出版信息

J Clin Biochem Nutr. 2007 Nov;41(3):154-9. doi: 10.3164/jcbn.2007021.

DOI:10.3164/jcbn.2007021
PMID:18299709
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2243239/
Abstract

Lansoprazole uptake sites by two kinds of autoradiographic procedures were compared with recent literature. The uptake sites have been seen in the Helicobacter pylori, colonic epithelial cells, inflammatory cells, peripheral autonomic nerves and enterochromaffinlike cells as well as gastric parietal cells. Each uptake sites corresponded to the reported localization of P-type ATPase or acidic compartment.

摘要

采用两种放射性自显影技术对兰索拉唑摄取部位进行了比较，并与近期文献进行了比较。摄取部位见于幽门螺杆菌、结肠上皮细胞、炎症细胞、周围自主神经和肠嗜铬样细胞以及胃壁细胞。每个摄取部位都与报道的 P 型 ATP 酶或酸性区室的定位相对应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5bf/2243239/12913e7199ea/jcbn2007052f03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5bf/2243239/31472779cde8/jcbn2007052f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5bf/2243239/e8629ad56982/jcbn2007052f02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5bf/2243239/12913e7199ea/jcbn2007052f03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5bf/2243239/31472779cde8/jcbn2007052f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5bf/2243239/e8629ad56982/jcbn2007052f02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5bf/2243239/12913e7199ea/jcbn2007052f03.jpg

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Cell Microbiol. 2007 Jun;9(6):1481-90. doi: 10.1111/j.1462-5822.2006.00886.x. Epub 2007 Jan 23.
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