Integrating sensitive quantification of hepatic metabolic functions by capillary electrophoresis with laser-induced fluorescence detection.

作者信息

Toh Yi-Chin, Zhang Jing, Khong Yuet Mei, Du Yanan, Sun Wanxin, Yu Hanry

机构信息

Institute of Biotechnology and Nanotechnology, A*STAR, The Nanos, #04-01, 31 Biopolis Way, Singapore 138669, Singapore.

出版信息

Analyst. 2008 Mar;133(3):326-30. doi: 10.1039/b716420c. Epub 2008 Feb 5.

We report the establishment of capillary electrophoresis with laser-induced fluorescence (CE-LIF) detection as a common analytical platform for sensitive quantification of both phase I and II metabolism in various hepatic in vitro models.