纹状体中钙结合蛋白和小白蛋白免疫反应性细胞对兴奋性毒素的差异敏感性。

Differential sensitivity of calbindin and parvalbumin immunoreactive cells in the striatum to excitotoxins.

作者信息

Waldvogel H J, Faull R L, Williams M N, Dragunow M

机构信息

Department of Anatomy, School of Medicine, University of Auckland, New Zealand.

出版信息

Brain Res. 1991 Apr 19;546(2):329-35. doi: 10.1016/0006-8993(91)91497-o.

DOI:10.1016/0006-8993(91)91497-o

PMID:1829975

Abstract

The neurotoxic effects of ibotenic acid, quinolinic acid and kainic acid on cells in the rat striatum were investigated using immunocytochemistry with antibodies to the calcium binding proteins, calbindin and parvalbumin. The results showed that both ibotenic acid and quinolinic acid affected calbindin and parvalbumin cells to the same extent. However, parvalbumin immunopositive neurons were more sensitive than calbindin immunopositive neurons to the neurotoxic effects of kainic acid. Although the reason for this increased sensitivity of parvalbumin striatal neurons to kainic acid is unclear, these results suggest that the neurotoxicity produced by kainic acid is different to that occurring with quinolinic acid and ibotenic acid.

摘要

使用针对钙结合蛋白、钙结合蛋白和小白蛋白的抗体进行免疫细胞化学，研究了鹅膏蕈氨酸、喹啉酸和红藻氨酸对大鼠纹状体细胞的神经毒性作用。结果表明，鹅膏蕈氨酸和喹啉酸对钙结合蛋白和小白蛋白细胞的影响程度相同。然而，小白蛋白免疫阳性神经元对红藻氨酸的神经毒性作用比钙结合蛋白免疫阳性神经元更敏感。尽管尚不清楚小白蛋白纹状体神经元对红藻氨酸敏感性增加的原因，但这些结果表明，红藻氨酸产生的神经毒性与喹啉酸和鹅膏蕈氨酸产生的神经毒性不同。