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围绝经期及绝经后早期女性从基线到随访2年期间的口腔健康状况与激素替代疗法的关系

Oral health in perimenopausal and early postmenopausal women from baseline to 2 years of follow-up with reference to hormone replacement therapy.

作者信息

Tarkkila L, Furuholm J, Tiitinen A, Meurman J H

机构信息

Institute of Dentistry, University of Helsinki, P.O. Box 41, 00014 Helsinki, Finland.

出版信息

Clin Oral Investig. 2008 Sep;12(3):271-7. doi: 10.1007/s00784-008-0190-z. Epub 2008 Feb 26.

Abstract

Female sex hormones also affect the mouth but there are little data on oral health of menopause age women. This 2-year follow-up study investigated oral health of perimenopausal and early postmenopausal women. Because hormone replacement therapy (HRT) users have been reported to be more health conscious than nonusers, we expected differences between women using and women not using HRT. Of 3,173 women, a random sample of 400 (200 using and 200 not using HRT) was examined. Of them, 161 case-control pairs of women using/not using HRT were reexamined 2 years later. Dental and periodontal status was recorded according to the WHO criteria and resting and stimulated saliva flow was measured. Panoramic tomography of the jaws was taken at baseline and at follow-up. The patients also filled in a structured questionnaire on their systemic health, medication, and health habits. The results were analyzed statistically between and within the groups. No difference was observed in any dental parameters or salivary flow rates between the groups. However, during the follow-up, women in HRT group had received more dental restorations (p<0.05) and they also reported more often recent dental appointments (p<0.05). Although no difference in oral health status or salivary flow rates between women using or not using HRT was found, the observation on dental restorations may indicate a more health conscious attitude in the HRT group.

摘要

女性性激素也会影响口腔,但关于绝经年龄女性口腔健康的数据较少。这项为期两年的随访研究调查了围绝经期和绝经后早期女性的口腔健康状况。由于据报道激素替代疗法(HRT)使用者比非使用者更注重健康,我们预计使用HRT和未使用HRT的女性之间会存在差异。在3173名女性中,随机抽取了400名(200名使用HRT,200名未使用HRT)进行检查。其中,161对使用/未使用HRT的病例对照女性在两年后接受了复查。根据世界卫生组织标准记录牙齿和牙周状况,并测量静息和刺激后的唾液流量。在基线和随访时拍摄颌骨全景断层扫描。患者还填写了一份关于其全身健康、用药和健康习惯的结构化问卷。对组间和组内结果进行统计学分析。两组之间在任何牙齿参数或唾液流速方面均未观察到差异。然而,在随访期间,HRT组女性接受的牙齿修复更多(p<0.05),她们也更频繁地报告最近有看牙记录(p<0.05)。尽管未发现使用或未使用HRT的女性在口腔健康状况或唾液流速方面存在差异,但关于牙齿修复的观察结果可能表明HRT组有更注重健康的态度。

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