Health Management Center, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, 410008, P.R. China.
Changsha Health Vocational College, Changsha, Hunan, 410605, P.R. China.
Clin Oral Investig. 2024 Nov 4;28(11):623. doi: 10.1007/s00784-024-06018-1.
We investigated the association of female reproductive factors with periodontitis.
This cross-sectional study analyzed data from the US National Health and Nutrition Examination Survey 2009-2014 on 2321 women aged 45-80 years who had full-mouth periodontal examination and reproductive questionnaire. The 2018 World Workshop Classification of Periodontal and Peri-implant Diseases was used to classify periodontitis stages.
After adjustment, > 3 pregnancies or live births were associated with increased stage III/IV periodontitis but age at first birth (AFB) > 23 years and female hormone use were associated with decreased stage III/IV periodontitis, while there were no associations of oral contraceptive use or menopause status with stage III/IV periodontitis. Stage III/IV periodontitis was more common in women with > 3 pregnancies or live births and AFB ≤ 23 years or never using female hormones but less common in women with ≥ 3 pregnancies or > 3 live births and AFB > 23 years or using female hormones. >3 pregnancies or live births were related with increased stage III/IV periodontitis and increased AFB was related with lowered stage III/IV periodontitis in overweight and smoking subgroups but using female hormone was related with reduced stage III/IV periodontitis in nonsmoking, non-overweight and black subgroups.
3 pregnancies/live births were related with severe periodontitis but AFB > 23 years and female hormone use were related with ameliorating periodontitis.
Women with > 3 pregnancies/live births should receive intensive periodontal interventions. Female hormone therapy or AFB > 23 years may be beneficial for periodontal health of > 3 pregnancies/live births women.
我们研究了女性生殖因素与牙周炎的关系。
本横断面研究分析了 2009-2014 年美国国家健康和营养调查中 2321 名年龄在 45-80 岁、接受全口牙周检查和生殖问卷的女性的数据。使用 2018 年世界牙周病和种植体周围病工作组分类来分类牙周炎阶段。
调整后，>3 次妊娠或活产与 III/IV 期牙周炎增加相关，但初产年龄（AFB）>23 岁和女性激素使用与 III/IV 期牙周炎减少相关，而口服避孕药使用或绝经状态与 III/IV 期牙周炎无关。>3 次妊娠或活产和 AFB≤23 岁或从未使用女性激素的女性更常见 III/IV 期牙周炎，而 AFB>23 岁或使用女性激素的女性则较少发生 III/IV 期牙周炎。>3 次妊娠或活产与 III/IV 期牙周炎增加有关，AFB 增加与超重和吸烟亚组的 III/IV 期牙周炎降低有关，但在不吸烟、非超重和黑人亚组中，使用女性激素与 III/IV 期牙周炎降低有关。
3 次妊娠/活产与严重牙周炎有关，但 AFB>23 岁和女性激素使用与改善牙周炎有关。
有>3 次妊娠/活产的女性应接受强化牙周干预。女性激素治疗或 AFB>23 岁可能对>3 次妊娠/活产的女性的牙周健康有益。
