Thommes Markus, Kleinebudde Peter
Institute of Pharmaceutics and Biopharmaceutics, Heinrich-Heine-University, Duesseldorf, Germany.
Pharm Dev Technol. 2008;13(1):27-35. doi: 10.1080/10837450701702537.
kappa-Carrageenan is known as a novel pelletization aid in manufacturing of pellets by extrusion/spheronization. The implentation of kappa-carrageenan as a pelletization aid can overcome several disadvantages of commonly used microcrystalline cellulose (MCC) such as lacking disintegration and adsorption of several actives. The aim of this study was to compare different types of carrageenans from different suppliers: one iota-, five kappa-, and one lambda-carrageenan. The kappa-carrageenans had the best pelletization behavior. Four of the five tested kappa-carrageenans resulted in pellets with acceptable shapes, sizes, and size distributions using a high drug load of 80% hydrochlorothiazide. These pellets have similar properties over a wide range of water contents ranging from 90 to 105%. The filler, dicalcium phosphate, affected the pelletization process and the pellet properties of all investigated kappa-carrageenans.
κ-角叉菜胶在通过挤出/滚圆法制造微丸过程中是一种新型制丸助剂。将κ-角叉菜胶用作制丸助剂可以克服常用微晶纤维素（MCC）的几个缺点，如缺乏崩解性以及对几种活性成分的吸附性。本研究的目的是比较来自不同供应商的不同类型角叉菜胶：一种ι-角叉菜胶、五种κ-角叉菜胶和一种λ-角叉菜胶。κ-角叉菜胶具有最佳的制丸性能。在使用80%高药物负载的氢氯噻嗪时，五种测试的κ-角叉菜胶中有四种制成的微丸具有可接受的形状、尺寸和尺寸分布。这些微丸在90%至105%的广泛含水量范围内具有相似的性质。填充剂磷酸氢钙影响了所有研究的κ-角叉菜胶的制丸过程和微丸性质。
