Lu Zhilei, Chen Weiyang, Hamman Josias H, Ni Jian, Zhai Xiaoling
Department of Pharmaceutical Sciences, Tshwane University of Technology, Pretoria, South Africa.
Pharm Dev Technol. 2008;13(1):37-47. doi: 10.1080/10837450701702636.
The in vitro performance of monolithic matrix systems containing the interpolyelectrolyte complex between chitosan and polycarbophil as excipient was evaluated in terms of their swelling, bioadhesive, and drug release properties. The different matrix systems showed excellent swelling properties without erosion, except for the formulation containing the highest quantity chitosan-polycarbophil complex that exhibited surface erosion in addition to swelling. All the different matrix systems exhibited significantly higher bioadhesive properties than the control group. Furthermore, they showed controlled insulin release without an initial burst release effect. However, only the matrix system that exhibited surface erosion in combination with swelling approached zero-order release.
对含有壳聚糖和聚卡波非之间的聚电解质复合物作为辅料的整体基质系统的体外性能，从其溶胀、生物黏附及药物释放特性方面进行了评估。除了含有最高量壳聚糖 - 聚卡波非复合物的制剂除了溶胀还表现出表面侵蚀外，不同的基质系统均表现出优异的无侵蚀溶胀特性。所有不同的基质系统均表现出比对照组显著更高的生物黏附特性。此外，它们显示出胰岛素的控释，没有初始突释效应。然而，只有表现出表面侵蚀并伴有溶胀的基质系统接近零级释放。
