Kucera Tomás, Eglinger Jan, Strilić Boris, Lammert Eckhard
Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr 108, D-01307 Dresden, Germany.
Novartis Found Symp. 2007;283:46-56; discussion 56-60, 238-41. doi: 10.1002/9780470319413.ch5.
Endothelial cells are equipped with the intrinsic ability to form tubes and sprouts with a central lumen. However, the mechanisms that allow endothelial cells to form a lumen are largely unknown. We would like to discuss critically current models of vascular lumen formation and point to many unexplored and open questions. We briefly present what vascular researchers can learn from the formation of other cell systems with a lumen, such as cysts formed by Madin-Darby Canine Kidney (MDCK) cells as well as tracheae formed by Drosophila epithelial cells. In addition, we point to a number of questions that need to be addressed to understand better the cell biology that drives the formation of a vascular lumen.
内皮细胞具备形成带有中央管腔的管状物和芽的内在能力。然而，使内皮细胞形成管腔的机制在很大程度上尚不清楚。我们将批判性地讨论当前血管管腔形成的模型，并指出许多未被探索的开放性问题。我们简要介绍血管研究人员可以从其他具有管腔的细胞系统形成过程中学到什么，例如由犬肾（MDCK）细胞形成的囊肿以及由果蝇上皮细胞形成的气管。此外，我们指出了一些为更好地理解驱动血管管腔形成的细胞生物学而需要解决的问题。
