Nguyen Thanh D, Spincemaille Pascal, Weinsaft Jonathan W, Ho Bernard Y, Cham Matthew D, Prince Martin R, Wang Yi
Department of Radiology, Weill Medical College of Cornell University, New York, New York 10022, USA.
J Magn Reson Imaging. 2008 Apr;27(4):802-8. doi: 10.1002/jmri.21296.
To develop a rapid navigator-gated three-dimensional (3DNAV) delayed-enhancement MRI (DE-MRI) sequence for myocardial viability assessment, and to evaluate its performance with breathhold two-dimensional (2DBH) DE-MRI sequence as the reference standard.
2DBH DE-MRI was initiated 10 minutes after contrast administration and followed by 3DNAV DE-MRI in 23 patients at 1.5 T. Comparison was performed using three qualitative criteria (image quality score, diagnostic outcome, relative diagnostic confidence score) in all patients, and three quantitative criteria (infarct volume, infarct signal-to-noise ratio [SNR(inf)], and infarct-viable myocardium contrast-to-noise ratio [CNR(inf-myo)]) in patients with hyperenhanced myocardium.
Compared to 2DBH DE-MRI, 3DNAV DE-MRI provided slightly better image quality, the same final diagnostic outcomes, and better relative diagnostic confidence score with 79% SNR(inf) improvement (P = 0.002) and 90% CNR(inf-myo) improvement (P = 0.004) in 39% less scan time (414 +/- 118 seconds for 2DBH and 251 +/- 93 seconds for 3DNAV). The measured infarct volumes demonstrated excellent correlation (18.9 +/- 19.0 mL for 2DBH DE-MRI vs. 17.6 +/- 19.0 mL for 3DNAV DE-MRI, r(2) = 0.998, P < 0.001, N = 7) and narrow limits of agreement (-1.3 +/- 1.8 mL).
3DNAV DE-MRI provides improved image quality and similar infarct detection in less scan time compared to the standard 2DBH DE-MRI.
研发一种用于评估心肌活力的快速导航门控三维（3DNAV）延迟增强磁共振成像（DE-MRI）序列，并以屏气二维（2DBH）DE-MRI序列作为参考标准评估其性能。
在1.5T场强下，对23例患者在注射造影剂10分钟后开始进行2DBH DE-MRI检查，随后进行3DNAV DE-MRI检查。对所有患者使用三种定性标准（图像质量评分、诊断结果、相对诊断置信度评分）进行比较，对心肌强化的患者使用三种定量标准（梗死体积、梗死信噪比[SNR(inf)]、梗死心肌与存活心肌对比噪声比[CNR(inf-myo)]）进行比较。
与2DBH DE-MRI相比，3DNAV DE-MRI图像质量略优，最终诊断结果相同，相对诊断置信度评分更高，扫描时间减少39%，SNR(inf)提高79%（P = 0.002），CNR(inf-myo)提高90%（P = 0.004）（2DBH为414±118秒，3DNAV为251±93秒）。测量的梗死体积显示出极好的相关性（2DBH DE-MRI为18.9±19.0 mL，3DNAV DE-MRI为17.6±19.0 mL，r(2)=0.998，P<0.001，N = 7），一致性界限狭窄（-1.3±1.8 mL）。
与标准的2DBH DE-MRI相比，3DNAV DE-MRI在更短的扫描时间内提供了更好的图像质量和相似的梗死检测效果。
