Department of Diagnostic, Interventional and Pediatric Radiology, Inselspital, Bern University Hospital, University of Bern, Freiburgstrasse, 3010, Bern, Switzerland.
Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Int J Cardiovasc Imaging. 2023 Jan;39(1):135-144. doi: 10.1007/s10554-022-02701-0. Epub 2022 Aug 23.
The aim of this study was to investigate the diagnostic accuracy and reader confidence for late-gadolinium enhancement (LGE) detection of a novel free-breathing, image-based navigated 3D whole-heart LGE sequence with fat-water separation, compared to a free-breathing motion-corrected 2D LGE sequence in patients with ischemic and non-ischemic cardiomyopathy. Cardiac MRI patients including the respective sequences were retrospectively included. Two independent, blinded readers rated image quality, depiction of segmental LGE and documented acquisition time, SNR, CNR and amount of LGE. Results were compared using the Friedman or the Kruskal-Wallis test. For LGE rating, a jackknife free-response receiver operating characteristic analysis was performed with a figure of merit (FOM) calculation. Forty-two patients were included, thirty-two were examined with a 1.5 T-scanner and ten patients with a 3 T-scanner. The mean acquisition time of the 2D sequence was significantly shorter compared to the 3D sequence (07:12 min vs. 09:24 min; p < 0.001). The 3D scan time was significantly shorter when performed at 3 T compared to 1.5 T (07:47 min vs. 09:50 min; p < 0.001). There were no differences regarding SNR, CNR or amount of LGE. 3D imaging had a significantly higher FOM (0.89 vs. 0.78; p < 0.001). Overall image quality ratings were similar, but 3D sequence ratings were higher for fine anatomical structures. Free-breathing motion-corrected 3D LGE with high isotropic resolution results in enhanced LGE-detection with higher confidence and better delineation of fine structures. The acquisition time for 3D imaging was longer, but may be reduced by performing on a 3 T-scanner.
本研究旨在比较新型自由呼吸、基于图像导航的 3D 全心 LGE 序列（具有水脂分离功能）与自由呼吸运动校正的 2D LGE 序列在缺血性和非缺血性心肌病患者中的诊断准确性和观察者信心。回顾性纳入包括这两种序列的心脏 MRI 患者。两位独立的、盲法的观察者评估了图像质量、节段性 LGE 的显示程度以及记录的采集时间、信噪比、对比噪声比和 LGE 量。使用 Friedman 或 Kruskal-Wallis 检验比较结果。LGE 评分采用刀切无应答者接受者操作特征分析，并计算了符合度（FOM）。共纳入 42 例患者，其中 32 例在 1.5T 扫描仪上进行检查，10 例在 3T 扫描仪上进行检查。2D 序列的平均采集时间明显短于 3D 序列（07:12 分钟比 09:24 分钟；p<0.001）。3T 时 3D 扫描时间明显短于 1.5T（07:47 分钟比 09:50 分钟；p<0.001）。SNR、CNR 或 LGE 量无差异。3D 成像的 FOM 显著更高（0.89 比 0.78；p<0.001）。总体图像质量评分相似，但 3D 序列对精细解剖结构的评分更高。具有高各向同性分辨率的自由呼吸运动校正 3D LGE 可提高 LGE 检测的置信度和精细结构的勾画能力。3D 成像的采集时间较长，但在 3T 扫描仪上进行时可缩短。
