Demirtürk Neşe, Demirdal Tuna, Erben Nurettin, Demir Serap, Asci Zerrin, Kilit Turkan Pasali, Kartal Elif Doyuk
Department of Infectious Disease and Clinical Microbiology, Kocatepe University, Afyon, Turkey.
Trop Doct. 2008 Jan;38(1):59-62. doi: 10.1258/td.2006.006266.
This retrospective study was performed in two university hospitals between January 2002 and 2006. Ninety-nine brucellosis patients were included in the study. These patients were classified as acute (91), chronic (4) and relapse (4) according to their clinical presentations and serological tests. Brucella bacteria were isolated in the blood of 17 (17.2%) cases. The most frequent symptom and clinical sign was fever. The osteoarticular complications were found in 17 patients (17.2%). Four of them were complicated with epidural abscess the same time. Two (2.2%) had meningitis, two (2.2%) had epididymoorchitis, three (3.3%) had skin rashes and one (1.1%) had hepatitis. Three of the acute brucellosis patients were pregnant. Rifampin and doxycycline combination therapy had been administered to most of the patients with acute and relapse brucellosis. However, complicated and chronic brucellosis cases were given different treatment combinations. This study reviews brucellosis therapy choices.
这项回顾性研究于2002年1月至2006年期间在两家大学医院开展。99例布鲁氏菌病患者纳入本研究。根据临床表现和血清学检测，这些患者被分为急性（91例）、慢性（4例）和复发（4例）。17例（17.2%）患者血液中分离出布鲁氏菌。最常见的症状和临床体征是发热。17例患者（17.2%）出现骨关节并发症。其中4例同时并发硬膜外脓肿。2例（2.2%）患有脑膜炎，2例（2.2%）患有附睾炎，3例（3.3%）出现皮疹，1例（1.1%）患有肝炎。3例急性布鲁氏菌病患者为孕妇。大多数急性和复发布鲁氏菌病患者接受利福平与强力霉素联合治疗。然而，复杂型和慢性布鲁氏菌病患者给予不同的治疗组合。本研究回顾了布鲁氏菌病的治疗选择。
