Degirmenci Berna, Miral Süha, Kaya Gamze Capa, Iyilikçi Leyla, Arslan Gulhan, Baykara Ayşen, Evren Ismail, Durak Hatice
Department of Nuclear Medicine, Dokuz Eylul University Medical School, 35340, Inciralti, Izmir, Turkey.
Psychiatry Res. 2008 Apr 15;162(3):236-43. doi: 10.1016/j.pscychresns.2004.12.005. Epub 2008 Mar 4.
The purpose of the study was to investigate perfusion patterns in autistic children (AC) and their families. Ten AC (9 boys, 1 girl; mean age: 6.9+/-1.7 years) with autistic disorder defined by DSM-III-R criteria, five age-matched children (3 boys, 2 girls) as a control group, and the immediate family members of eight AC (8 mothers, 8 fathers, 7 siblings; mean ages: 39+/-4 years, 36+/-5 years and 13+/-5 years, respectively) were included in the study. Age- and sex-matched control groups for both the parents and the siblings were also included in the study. Brain perfusion images were obtained 1 h after the intravenous injection of an adjusted dose of Tc-99m HMPAO to children and the adults. Visual and semiquantitative evaluations were performed. Hypoperfusion was seen in the right posterior parietal cortex in three AC, in bilateral parietal cortex in one AC, bilateral frontal cortex in two AC, left parietal and temporal cortex in one AC, and right parietal and temporal cortex in one AC. Asymmetric perfusion was observed in the caudate nucleus in four AC. In semiquantitative analyses, statistically significant hypoperfusion was found in the right inferior and superior frontal, left superior frontal, right parietal, right mesial temporal and right caudate nucleus. In parents of AC, significant hypoperfusion was noted in the right parietal and bilateral inferior frontal cortex. In siblings of AC, perfusion in the right frontal cortex, right nucleus caudate and left parietal cortex was significantly decreased. This preliminary study suggests the existence of regional brain perfusion alterations in frontal, temporal, and parietal cortex and in caudate nucleus in AC and in their first-degree family members.
本研究的目的是调查自闭症儿童（AC）及其家庭成员的灌注模式。10名符合DSM-III-R标准定义的自闭症障碍的AC儿童（9名男孩，1名女孩；平均年龄：6.9±1.7岁）、5名年龄匹配的儿童（3名男孩，2名女孩）作为对照组，以及8名AC儿童的直系家庭成员（8名母亲、8名父亲、7名兄弟姐妹；平均年龄分别为39±4岁、36±5岁和13±5岁）被纳入研究。研究中还包括了年龄和性别匹配的父母及兄弟姐妹对照组。在儿童和成人静脉注射调整剂量的Tc-99m HMPAO 1小时后获取脑灌注图像。进行了视觉和半定量评估。3名AC儿童右侧顶叶后部皮质出现灌注不足，1名AC儿童双侧顶叶皮质出现灌注不足，2名AC儿童双侧额叶皮质出现灌注不足，1名AC儿童左侧顶叶和颞叶皮质出现灌注不足，1名AC儿童右侧顶叶和颞叶皮质出现灌注不足。4名AC儿童尾状核观察到不对称灌注。在半定量分析中，右侧额下回和额上回、左侧额上回、右侧顶叶、右侧颞中回和右侧尾状核发现有统计学意义的灌注不足。在AC儿童的父母中，右侧顶叶和双侧额下回皮质出现明显灌注不足。在AC儿童的兄弟姐妹中，右侧额叶皮质、右侧尾状核和左侧顶叶皮质的灌注明显减少。这项初步研究表明，AC儿童及其一级家庭成员的额叶、颞叶和顶叶皮质以及尾状核存在局部脑灌注改变。
