Nijboer Tanja C W, McIntosh Rob D, Nys Gudrun M S, Dijkerman H Chris, Milner A David
Department of Experimental Psychology, Utrecht University, Utrecht, The Netherlands.
Neuroreport. 2008 Feb 12;19(3):293-8. doi: 10.1097/WNR.0b013e3282f4cb67.
Prism adaptation has been shown to temporarily ameliorate the symptoms of unilateral neglect. The underlying mechanisms of change are not yet fully understood. In this study, we investigate the influence of this treatment on attentional orienting under conditions of exogenous (peripheral onset) and endogenous (central symbolic) cueing. In one patient with left visual extinction and recovered neglect, and another patient with left visual neglect, visuo-motor adaptation to a rightward prismatic shift of 10 degrees improved leftward orienting of attention following an endogenous but not an exogenous cue; leftward re-orienting of attention was also improved in the endogenous task for the second patient. We suggest that prism adaptation may ameliorate neglect by improving compensatory processes of leftward voluntary orienting, rather than by a fundamental change in attentional bias.
棱镜适应已被证明可暂时改善单侧忽视的症状。其潜在的变化机制尚未完全明确。在本研究中，我们调查了这种治疗在外源性（外周起始）和内源性（中央符号）提示条件下对注意力定向的影响。在一名患有左侧视觉消退和已恢复忽视的患者以及另一名患有左侧视觉忽视的患者中，对10度向右棱镜偏移的视觉运动适应改善了内源性而非外源性提示后注意力的向左定向；第二名患者在内源性任务中注意力的向左重新定向也得到了改善。我们认为，棱镜适应可能通过改善向左自愿定向的代偿过程来改善忽视，而不是通过注意力偏差的根本改变。
