Glize Bertrand, Lunven Marine, Rossetti Yves, Revol Patrice, Jacquin-Courtois Sophie, Klinger Evelyne, Joseph Pierre-Alain, Rode Gilles
Centre de Recherche en Neurosciences de Lyon, ImpAct Team, Institut National de la Santé et de la Recherche Médicale U1028, Centre National de la Recherche Scientifique UMR5292, Université Claude Bernard Lyon 1, Lyon, France.
Service de Médecine Physique et de Réadaptation, Hôpital Henry Gabrielle, Hospices Civils de Lyon, Lyon, France.
Front Psychol. 2017 Nov 20;8:2019. doi: 10.3389/fpsyg.2017.02019. eCollection 2017.
Prism adaptation (PA) is responsible for an expansion of sensori-motor after-effects to cognitive domains for patients with spatial neglect. One important question is whether the cognitive after-effects induced by PA may also concern higher aspects of spatial cognition, such as navigation and topographic memory, which are critical in everyday life. The aim of this study was to assess whether multiple sessions of right PA can affect navigation and topographic memory. Seven right brain-damaged (RBD) patients with chronic neglect were included. We used a virtual supermarket named VAP-S which is an original paradigm, similar to the "shopping list test" during which patients had to purchase items from a list of eight products. Furthermore, in order to assess generalization of PA effects on constructing a spatial map from virtual information, each participant was then asked to draw the map of the virtual supermarket from memory. Regarding navigation performance, significant results were obtained: session duration reduction, fewer numbers of pauses and omissions, more items purchased on the left side and more items purchased over all. A long-lasting effect was noted, up to one month after PA. The representational task performance was also significantly increased for map drawing, with a reduction of the right shift of the symmetry axis of the map, more items drawn on the left side of maps and over all, and more items correctly located on the map. Some of these effects lasted for at least 7 days. These results suggest an expansion of PA benefit to a virtual environment. Crucially, the cognitive benefits induced by PA were noted for complex spatial cognition tasks required in everyday life such as navigation and topographic memory and this improvement was maintained for up to 1 month.
棱镜适应（PA）可使空间忽视患者的感觉运动后效扩展至认知领域。一个重要问题是，PA诱导的认知后效是否也涉及空间认知的更高层面，如导航和地形记忆，而这些在日常生活中至关重要。本研究旨在评估多次右侧PA是否会影响导航和地形记忆。纳入了7名患有慢性忽视的右脑损伤（RBD）患者。我们使用了一个名为VAP-S的虚拟超市，这是一种原创范式，类似于“购物清单测试”，在此过程中患者必须从八种产品的清单中购买物品。此外，为了评估PA对根据虚拟信息构建空间地图的影响的泛化情况，随后要求每位参与者凭记忆绘制虚拟超市的地图。关于导航表现，获得了显著结果：会话时长缩短、停顿和遗漏次数减少、左侧购买的物品增多以及总体购买的物品增多。观察到了持久效应，在PA后长达一个月。地图绘制的表征任务表现也显著提高，地图对称轴的右移减少，地图左侧绘制的物品增多且总体增多，地图上正确定位的物品增多。其中一些效应持续了至少7天。这些结果表明PA的益处扩展到了虚拟环境。至关重要的是，PA诱导的认知益处体现在日常生活所需的复杂空间认知任务上，如导航和地形记忆，并且这种改善持续了长达1个月。
