Costanzo Richard M, Perrino Lisa A
Department of Physiology, School of Medicine, Virginia Commonwealth University, Richmond, Virginia, USA.
Neuroreport. 2008 Feb 12;19(3):327-31. doi: 10.1097/WNR.0b013e3282f50c7b.
Matrix metalloproteineases are associated with extracellular remodeling that occurs in injury and repair processes in the central nervous system (CNS). We examined the role of MMP-2 in a model of olfactory nerve injury and found that MMP-2 levels increased several hours following injury, peaked at day 7 and then decreased rapidly. We previously reported a rapid increase in MMP-9, within 5 h after nerve injury, corresponding to neuronal degeneration and increased glial activity. In this study, we show that MMP-2 peaks later than MMP-9, at the onset of neuronal regeneration and repair. Using MMP-9 knockout mice, we determined that the MMP-2 increase is independent of MMP-9. Our data suggest that MMP-2 and MMP-9 may play different roles in the injury and repair processes.
基质金属蛋白酶与中枢神经系统（CNS）损伤和修复过程中发生的细胞外重塑有关。我们在嗅神经损伤模型中研究了MMP-2的作用，发现损伤后数小时MMP-2水平升高，在第7天达到峰值，然后迅速下降。我们之前报道过，神经损伤后5小时内MMP-9迅速增加，这与神经元变性和神经胶质细胞活性增加相对应。在本研究中，我们表明MMP-2在神经元再生和修复开始时比MMP-9达到峰值的时间更晚。使用MMP-9基因敲除小鼠，我们确定MMP-2的增加独立于MMP-9。我们的数据表明，MMP-2和MMP-9在损伤和修复过程中可能发挥不同的作用。
