Mirani Putri, Murti Krisna, Lestari Peby Maulina, Liberty Iche Andriyani, Kesty Cindy, Andrina Hana, Stevanny Bella
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Dr. Mohammad Hoesin General Hospital, Faculty of Medicine, Universitas Sriwijaya, Palembang 30114, South Sumatra, Indonesia.
Department of Anatomic Pathology, Dr. Mohammad Hoesin General Hospital, Faculty of Medicine, Universitas Sriwijaya, Palembang 30114, South Sumatra, Indonesia.
Medicina (Kaunas). 2025 Mar 6;61(3):461. doi: 10.3390/medicina61030461.
: The pathogenesis of placenta accreta spectrum disorder (PASD) is influenced by the inflammatory process. Therefore, the examination of biomarkers related to the inflammatory process, namely matrix metalloproteinase (MMP) and CXC motif chemokine receptor 2 (CXCR2), is expected to bring researchers to a bright spot regarding the pathogenesis of PASD. This study analyzes the role of CXCR2, MMP-2, and MMP-9 in the pathogenesis of PASD. : An observational study with a case-control design was conducted to assess differences in the mean density of CXCR2, MMP-2, and MMP-9 immunostaining in placental and uterine tissue in 17 patients with PASD and 34 patients without PASD at the Department of Obstetrics and Gynecology, Dr. Mohammad Hoesin Hospital Palembang. The expression of CXCR2, MMP-2, and MMP-9 was measured by immunohistochemistry analysis. The data were analyzed using STATA version 15. : There were no significant differences in the mean levels of MMP-2 expression in patients with and without PASD. There were significant differences in the expression of placental CXCR2 ( = 0.003), uterine CXCR2 ( < 0.001), and uterine MMP-9 ( = 0.018) in patients with and without PASD. : CXCR2 and MMP-9 may play a role in the pathogenesis of PASD.
胎盘植入谱系障碍（PASD）的发病机制受炎症过程影响。因此，对与炎症过程相关的生物标志物，即基质金属蛋白酶（MMP）和CXC基序趋化因子受体2（CXCR2）的检测，有望为研究人员揭示PASD发病机制带来一线曙光。本研究分析了CXCR2、MMP - 2和MMP - 9在PASD发病机制中的作用。
在巨港穆罕默德·霍辛博士医院妇产科，对17例PASD患者和34例非PASD患者进行了一项病例对照设计的观察性研究，以评估胎盘和子宫组织中CXCR2、MMP - 2和MMP - 9免疫染色的平均密度差异。通过免疫组织化学分析测定CXCR2、MMP - 2和MMP - 9的表达。数据使用STATA 15版进行分析。
PASD患者和非PASD患者的MMP - 2表达平均水平无显著差异。PASD患者和非PASD患者的胎盘CXCR2（P = 0.003）、子宫CXCR2（P < 0.001）和子宫MMP - 9（P = 0.018）表达存在显著差异。
CXCR2和MMP - 9可能在PASD的发病机制中起作用。
