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[玻璃体切除术后间接损伤性白内障形成的发病机制及预防策略]

[Pathogenesis and prevention strategies of indirect injured cataract formation after vitrectomy].

作者信息

Liu Xiaocui, Wang Ping, Yan Hong

机构信息

Department of Ophthalmology, Tangdu Hospital, The 4th Military Medical University, Xi' an 710038, China.

出版信息

Yan Ke Xue Bao. 2007 Dec;23(4):252-6.

Abstract

Vitrectomy has been widely used in medical practice, especially in treatment of diseases such as vitreous body diseases, retinal diseases and ocular injury. Epidemiological studies have indicated that under the circumstance of injuring the lens indirectly after vitrectomy, the incidence of nuclear cataract is obviously increasing, the mechanism and the prevention as well as cure of which is still the live topic in this field. Many studies had manifested that the main mechanism of the high incidence of cataract after vitrectomy included the physical and chemical changes of vitreous body, time of operation, age of patients, diseases of the eye, and uveitis after vitrectomy, etc. The most important factor is that vitrectomy increased oxygen exposure to the lens. Therefore, the measure of decreasing oxygen concentration and the treatment of Zinc-desferrioxamine may reduce the incidence of cataract, which provides a new way for the prevention and treatment of cataract after vitrectomy.

摘要

玻璃体切割术在医学实践中已被广泛应用,尤其是在治疗玻璃体疾病、视网膜疾病和眼外伤等疾病方面。流行病学研究表明,在玻璃体切割术后间接损伤晶状体的情况下,核性白内障的发病率明显增加,其发病机制以及防治仍是该领域的热门话题。许多研究表明,玻璃体切割术后白内障高发的主要机制包括玻璃体的物理和化学变化、手术时间、患者年龄、眼部疾病以及玻璃体切割术后的葡萄膜炎等。最重要的因素是玻璃体切割术增加了晶状体的氧暴露。因此,降低氧浓度的措施以及去铁胺锌的治疗可能会降低白内障的发病率,这为玻璃体切割术后白内障的防治提供了新途径。

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