Marinescu Smaranda C, Nishimata Toyoki, Mohr Justin T, Stoltz Brian M
Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Org Lett. 2008 Mar 20;10(6):1039-42. doi: 10.1021/ol702821j. Epub 2008 Feb 28.
General homogeneous conditions for the palladium-catalyzed synthesis of carbonyl compounds with tertiary carbon stereocenters at the alpha-position are reported. The highly reactive catalyst tolerates a variety of substrate substitution and functionality, and generates enantioenriched cyclic ketones from racemic allyl beta-ketoester starting materials.
报道了钯催化合成在α位具有叔碳立体中心的羰基化合物的一般均相条件。这种高活性催化剂能耐受多种底物取代和官能团,并能从外消旋烯丙基β-酮酯原料生成对映体富集的环状酮。