Sachithanandan Anand, Nanjaiah Prakash, Wright Christine J, Rooney Stephen J
Department of Cardiothoracic Surgery, University Hospital Birmingham NHS Trust, Queen Elizabeth Medical Centre, Birmingham B15 2TH, UK.
J Card Surg. 2008 Mar-Apr;23(2):167-8. doi: 10.1111/j.1540-8191.2007.00527.x.
Homozygous sickle cell disease (SCD) presents a multitude of challenges in patients undergoing cardiac surgery with cardiopulmonary bypass. Special consideration must be made in such patients and routine practice modified to prevent hypoxia, hypothermia, acidaemia and low-flow states which may potentially trigger a fatal sickling crisis perioperatively. We discuss several perioperative management strategies including a preoperative exchange transfusion, high flow normothermic bypass and warm blood cardioplegia that was utilized in a woman with homozygous SCD who underwent a successful double valve procedure.
纯合子镰状细胞病（SCD）给接受体外循环心脏手术的患者带来了诸多挑战。对此类患者必须给予特别考虑，并对常规做法进行调整，以预防可能在围手术期引发致命镰状细胞危象的低氧血症、体温过低、酸血症和低流量状态。我们讨论了几种围手术期管理策略，包括术前换血、高流量常温体外循环和温血心脏停搏液，这些策略应用于一名接受了成功双瓣膜手术的纯合子SCD女性患者。
