Nazaret Christine, Mazat Jean-Pierre
IMB, Université de Bordeaux 2, 146 Rue Léo-Saignat, F 33076 Bordeaux-cedex, France.
J Theor Biol. 2008 Jun 7;252(3):520-9. doi: 10.1016/j.jtbi.2008.01.003. Epub 2008 Jan 15.
We revisit an old Russian paper by V.V. Dynnik, R. Heinrich and E.E. Sel'kov (1980a,b) describing: "A mathematical model of carbohydrate energy metabolism. Interaction between glycolysis, the Krebs cycle and the H-transporting shuttles at varying ATPases load". We analyse the model mathematically and calculate the control coefficients as a function of ATPase loads. We also evaluate the structure of the metabolic network in terms of elementary flux modes. We show how this model can respond to an ATPase load as well as to the glucose supply. We also show how this simple model can help in understanding the articulation between the major blocks of energetic metabolism, i.e. glycolysis, the Krebs cycle and the H-transporting shuttles.
我们重新审视了V.V. 迪尼克、R. 海因里希和E.E. 塞尔科夫于1980年发表的两篇俄罗斯旧论文,论文描述了:“碳水化合物能量代谢的数学模型。不同ATP酶负荷下糖酵解、三羧酸循环和H转运穿梭系统之间的相互作用”。我们对该模型进行了数学分析,并计算了作为ATP酶负荷函数的控制系数。我们还根据基本通量模式评估了代谢网络的结构。我们展示了该模型如何响应ATP酶负荷以及葡萄糖供应。我们还展示了这个简单的模型如何有助于理解能量代谢主要模块之间的衔接,即糖酵解、三羧酸循环和H转运穿梭系统。