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达托霉素对多重耐药金黄色葡萄球菌以及具有已知毒力因子的金黄色葡萄球菌（包括社区获得性耐甲氧西林分离株）的体外活性。

In vitro activity of daptomycin against multidrug-resistant Staphylococcus aureus and S. aureus with known virulence factors, including community-acquired methicillin-resistant isolates.

作者信息

Anastasiou Diane M, Morgan Margie, Ruane Peter J, Steenbergen Judith N, Katz Bradley D, Alder Jeff D, Thorne Grace M

机构信息

Cubist Pharmaceuticals Inc., Lexington, MA 02421, USA.

出版信息

Diagn Microbiol Infect Dis. 2008 Jul;61(3):339-42. doi: 10.1016/j.diagmicrobio.2008.01.012. Epub 2008 Mar 4.

DOI:10.1016/j.diagmicrobio.2008.01.012
PMID:18304772
Abstract

The in vitro activity of daptomycin was evaluated against 360 multidrug-resistant Staphylococcus aureus isolates (including hospital-acquired isolates) and multidrug-susceptible community-acquired methicillin-resistant S. aureus with known virulence genes. All isolates were inhibited at <or=1 microg/mL, suggesting that daptomycin has excellent activity against both hospital-acquired and community-acquired S. aureus isolates.

摘要

对达托霉素的体外活性进行了评估，受试对象为360株多重耐药金黄色葡萄球菌分离株（包括医院获得性分离株）以及具有已知毒力基因的多重药物敏感的社区获得性耐甲氧西林金黄色葡萄球菌。所有分离株在浓度≤1微克/毫升时均受到抑制，这表明达托霉素对医院获得性和社区获得性金黄色葡萄球菌分离株均具有出色的活性。

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引用本文的文献

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The global prevalence of Daptomycin, Tigecycline, Quinupristin/Dalfopristin, and Linezolid-resistant Staphylococcus aureus and coagulase-negative staphylococci strains: a systematic review and meta-analysis.全球达托霉素、替加环素、奎奴普丁/达福普汀和利奈唑胺耐药金黄色葡萄球菌和凝固酶阴性葡萄球菌菌株的流行情况：系统评价和荟萃分析。
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