Lu Yong-Chen, Yeh Wen-Chen, Ohashi Pamela S
The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, 610 University Avenue, Toronto, Ont., Canada M5G 2M9; Department of Medical Biophysics, University of Toronto, Toronto, Ont., Canada M5G 2C1.
The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, 610 University Avenue, Toronto, Ont., Canada M5G 2M9; Department of Medical Biophysics, University of Toronto, Toronto, Ont., Canada M5G 2C1.
Cytokine. 2008 May;42(2):145-151. doi: 10.1016/j.cyto.2008.01.006. Epub 2008 Mar 4.
The stimulation of Toll-like receptor 4 (TLR4) by lipopolysaccharide (LPS) induces the release of critical proinflammatory cytokines that are necessary to activate potent immune responses. LPS/TLR4 signaling has been intensively studied in the past few years. Here we review molecules involved in TLR4-mediated signaling, including players that are involved in the negative regulation of this important pathway.
脂多糖（LPS）对Toll样受体4（TLR4）的刺激可诱导关键促炎细胞因子的释放，这些细胞因子是激活强大免疫反应所必需的。在过去几年中，LPS/TLR4信号传导已得到深入研究。在此，我们综述参与TLR4介导信号传导的分子，包括参与这一重要途径负调控的相关分子。
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