来自剑叶凤尾蕨的新苯甲酰葡萄糖苷和具有细胞毒性的蕨素倍半萜
New benzoyl glucosides and cytotoxic pterosin sesquiterpenes from Pteris ensiformis Burm.
作者信息
Chen Yung-Husan, Chang Fang-Rong, Lu Mei-Chin, Hsieh Pei-Wen, Wu Ming-Jiuan, Du Ying-Chi, Wu Yang-Chang
机构信息
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
出版信息
Molecules. 2008 Feb 5;13(2):255-66. doi: 10.3390/molecules13020255.
Three new compounds: 2R,3R-pterosin L 3-O-beta-D-glucopyranoside (1), beta-D-xylopyranosyl(1-->2)-7-O-benzoyl-beta-D-glucopyranoside (2) and 4-O-benzoyl-beta-D-xylo-pyranosyl(1-->2)-7-O-benzoyl-beta-D-glucopyranoside (3), together with nine known compounds, were isolated from the ethyl acetate extract of Pteris ensiformis. 5-[2-Hydroxyethylidene]-2(5H)-furanone (4), which had been synthesized, was isolated from natural sources for the first time. The structures of all isolated compounds were determined on the basis of mass and spectroscopic evidence. Compound 1 and pterosin B (5) show cytotoxicity against HL 60 cells (human leukemia) with the IC(50) values of 3.7 and 8.7 microg/mL, respectively.
从剑叶凤尾蕨的乙酸乙酯提取物中分离出三种新化合物
2R,3R-蕨素L 3-O-β-D-吡喃葡萄糖苷（1）、β-D-吡喃木糖基（1→2）-7-O-苯甲酰基-β-D-吡喃葡萄糖苷（2）和4-O-苯甲酰基-β-D-吡喃木糖基（1→2）-7-O-苯甲酰基-β-D-吡喃葡萄糖苷（3），以及九种已知化合物。5-[2-羟基亚乙基]-2(5H)-呋喃酮（4）已被合成，此次首次从天然来源中分离得到。所有分离出的化合物的结构均通过质谱和光谱证据确定。化合物1和蕨素B（5）对HL 60细胞（人白血病细胞）具有细胞毒性，IC(50)值分别为3.7和8.7μg/mL。
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