凤尾蕨中的凤尾菌素。

Pterosins from Pteris multifida.

机构信息

Department of Chinese Traditional Medicine, Shanghai Institute of Pharmaceutical Industry, Shanghai, P R China.

出版信息

Planta Med. 2010 Nov;76(16):1896-900. doi: 10.1055/s-0030-1249934. Epub 2010 May 19.

PMID:20486077

Abstract

A new C(14) pterosin sesquiterpenoid, named (2R)-pterosin P (1), and a new natural product, named dehydropterosin B (3), were isolated from the aerial parts of Pteris multifida Poir., along with nine known compounds (2, 4-11). By chiral HPLC, compounds 1 and 2 were isolated as a pair of enantiomeric pterosin sesquiterpenoids. The planar structure of 1 was elucidated on the basis of NMR spectroscopy analysis, and the absolute configuration was established by the CD spectrum. In addition, the absolute structure of 1 was further confirmed by single-crystal X-ray diffraction (CuK α). Compounds 3, 5, and 6 showed potent cytotoxicity against PANC-1 (human pancreatic cancer) and NCI-H446 (human small-cell lung cancer) cell lines, with IC(50) values in the range of 4.27-14.63 µM.

摘要

从凤尾蕨的地上部分分离得到一个新的 C(14) 倍半萜 pterosin，命名为（2R）-pterosin P（1），以及一个新的天然产物，命名为脱水 pterosin B（3），此外还有 9 个已知化合物（2、4-11）。通过手性 HPLC，化合物 1 和 2 被分离为一对对映体倍半萜 pterosin。基于 NMR 光谱分析阐明了 1 的平面结构，并通过 CD 光谱确定了绝对构型。此外，通过单晶 X 射线衍射（CuK α）进一步确证了 1 的绝对结构。化合物 3、5 和 6 对 PANC-1（人胰腺癌细胞）和 NCI-H446（人小细胞肺癌细胞）细胞系表现出强烈的细胞毒性，IC(50) 值范围为 4.27-14.63 μM。