从 中分离得到的四个新的翼手龙素及其细胞毒性活性。
Four New Pterosins from and Their Cytotoxic Activities.
机构信息
Key Laboratory of Modern Preparation of Traditional Chinese Medicines, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China.
出版信息
Molecules. 2019 Jul 30;24(15):2767. doi: 10.3390/molecules24152767.
Phytochemical investigation of the aerial parts of led to the isolation and elucidation of nine pterosins, including four new pterosins, creticolacton A (), 13-hydroxy-2(),3()-pterosin L (), creticoside A (), and spelosin 3--β-d-glucopyranoside (), together with five known pterosins -. Their structures were identified mainly on the basis of 1D and 2D NMR spectral data, ESI-MS and literature comparisons. Compounds and were new type of petrosins with a six membered ring between C-14 and C-15. The new compounds were tested in vitro for their cytotoxic activities against four human tumor cell lines (SH-SY5Y, SGC-7901, HCT-116, Lovo). Results showed that compounds and exhibited cytotoxic activity against HCT-116 cells with IC value of 22.4 μM and 15.8 μM, respectively.
对 led 的地上部分进行的植物化学研究导致分离和阐明了九种 pterosins，包括四种新的 pterosins，creticolacton A ()，13-hydroxy-2()，3()-pterosin L ()，creticoside A ()和 spelosin 3--β-d-吡喃葡萄糖苷 ()，以及五种已知的 pterosins - 。它们的结构主要是根据 1D 和 2D NMR 光谱数据、ESI-MS 和文献比较来确定的。化合物 和 是具有 C-14 和 C-15 之间六元环的新型 petrosins。新化合物在体外对四种人肿瘤细胞系（SH-SY5Y、SGC-7901、HCT-116、Lovo）进行了细胞毒性活性测试。结果表明，化合物 和 对 HCT-116 细胞具有细胞毒性活性，IC 值分别为 22.4 μM 和 15.8 μM。
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