Everitt B J, Morris K A, O'Brien A, Robbins T W
Department of Anatomy, University of Cambridge, U.K.
Neuroscience. 1991;42(1):1-18. doi: 10.1016/0306-4522(91)90145-e.
The effects on the expression of a conditioned place preference of bilateral, excitotoxic amino acid-induced lesions of the basolateral region of the amygdala, or the ventral striatum, or asymmetric, unilateral lesions of both structures were studied. The place preference was conditioned by exposing hungry rats to sucrose in a distinctive environment. Following acquisition, bilateral quisqualate-induced lesions of the basolateral amygdala, as well as bilateral quinolinate-induced lesions of the ventral striatum, abolished the conditioned place preference. Bilateral ventromedial, but not dorsolateral, quinolinate-induced caudate-putamen lesions attenuated the place preference. Combining a unilateral lesion of the basolateral amygdala with a contralateral lesion of the ventral striatum also disrupted the conditioned place preference. These data provide further support for the hypothesis that the basolateral amygdala and ventral striatum are important parts of a neural system subserving stimulus-reward associations.
研究了双侧、兴奋性毒性氨基酸诱导的杏仁核基底外侧区或腹侧纹状体损伤，以及这两个结构的不对称单侧损伤对条件性位置偏好表达的影响。通过将饥饿的大鼠置于一个独特环境中接触蔗糖来建立位置偏好。习得后，双侧喹啉酸诱导的杏仁核基底外侧损伤以及双侧喹啉酸诱导的腹侧纹状体损伤消除了条件性位置偏好。双侧腹内侧而非背外侧喹啉酸诱导的尾状核 - 壳核损伤减弱了位置偏好。将杏仁核基底外侧的单侧损伤与腹侧纹状体的对侧损伤相结合也破坏了条件性位置偏好。这些数据为杏仁核基底外侧和腹侧纹状体是服务于刺激 - 奖励关联的神经系统的重要组成部分这一假说提供了进一步支持。
