Doco-Lecompte T, Molina J M, Leleu-Nahmias G, Modaï J
Clinique des Maladies infectieuses, Hôpital Saint-Louis, Paris.
Presse Med. 1991 Jun 29;20(25):1159-62.
Thrombotic microangiopathy (TMA) is an anatomical entity which includes haemolytic-uraemic syndrome as well as thrombotic thrombocytopenic purpura. The physiopathology of TMA has not yet been fully elucidated, but it is certainly multifactorial. TMA has been described in numerous viral infections including HIV infection, and this raises the problem of relationship between the virus itself, the immunological phenomena it produces and the vascular walls. Three cases observed over a 2-year period are reported. In HIV infected patients anaemia, thrombocytopenia, renal failure and neurological abnormalities have multiple causes, and clinicians who look after these patients must be warned of the risk of TMA. TMA is difficult to treat, and its prognosis is extremely severe.
血栓性微血管病（TMA）是一种包括溶血尿毒综合征以及血栓性血小板减少性紫癜的解剖学实体。TMA的生理病理学尚未完全阐明，但肯定是多因素的。TMA已在包括HIV感染在内的多种病毒感染中被描述，这就引发了病毒本身、其产生的免疫现象与血管壁之间关系的问题。报告了在两年期间观察到的三例病例。在HIV感染患者中，贫血、血小板减少、肾衰竭和神经异常有多种原因，照顾这些患者的临床医生必须警惕TMA的风险。TMA难以治疗，其预后极其严重。
