Li Xiao-Rong, Wang Li-Juan, Li Yu-Hang, Xu Yan-Xia, Chen Yi, Ruan Jin-Xiu, Xue Ming
Department of Pharmacology, School of Chemical Biology and Pharmaceutical Sciences Institute of Material Medical, Capital Medical University, Beijing 100069, China.
Zhongguo Zhong Yao Za Zhi. 2007 Oct;32(20):2177-81.
The study investigates the protective effect on liver of Danxionfang and its components.
Mice are injected with CCl4 to establish liver injured model. ALT, AST, serum albumin, globulin in serum and SOD, MDA in liver and liver histological changes were measured to confirm the ability of protecting liver of Danxiongfang.
The results show Danxiongfang can inhibit obviously the abnormal increase of ALT, AST in serum and MDA in liver, enhance SOD activity in liver, total protein, albumin, globulin in serum, and decrease liver pathological changes, which suggests Danxiongfang can protect injured liver induced by CCl4.
Danxiongfang showed powerful protective effect against liver damage induced by CCl4.
研究丹芎方及其成分对肝脏的保护作用。
给小鼠注射四氯化碳建立肝损伤模型。检测血清中的谷丙转氨酶（ALT）、谷草转氨酶（AST）、血清白蛋白、球蛋白以及肝脏中的超氧化物歧化酶（SOD）、丙二醛（MDA），并观察肝脏组织学变化，以确认丹芎方的保肝能力。
结果表明，丹芎方能明显抑制血清中ALT、AST以及肝脏中MDA的异常升高，增强肝脏中SOD活性、血清总蛋白、白蛋白、球蛋白含量，并减轻肝脏病理变化，这表明丹芎方能保护由四氯化碳诱导的损伤肝脏。
丹芎方对四氯化碳诱导的肝损伤显示出强大的保护作用。
