Pyzhik T N, Obrosova I G
Vopr Pitan. 1991 Mar-Apr(2):49-51.
The influence of nicotinamide and oxythiamine on the activity of NADPH-producing dehydrogenases of glucoso-6-phosphate, 6-phosphogluconate, malate, isocitrate, as well as concentration and synthesis rate of fatty acids in fatty tissue were studied in experiments on mice with genetically conditioned non-insulin-dependent diabetes and hyperinsulinemia. It has been established that in these diseases the synthesis of fatty acids and their inclusion into lipids are activated without increasing the above enzymes activity. It is shown that nicotinamide and oxythiamine inhibit inclusion of C from glucose into free fatty acids, antivitamin intensifies lipolysis in the fatty tissue of the diseased animals.
在患有遗传性非胰岛素依赖型糖尿病和高胰岛素血症的小鼠实验中，研究了烟酰胺和氧化硫胺对葡萄糖 - 6 - 磷酸、6 - 磷酸葡萄糖酸、苹果酸、异柠檬酸的NADPH生成脱氢酶活性以及脂肪组织中脂肪酸浓度和合成速率的影响。已确定在这些疾病中，脂肪酸的合成及其掺入脂质的过程被激活，而上述酶的活性并未增加。结果表明，烟酰胺和氧化硫胺抑制葡萄糖中的C掺入游离脂肪酸，抗维生素加剧患病动物脂肪组织中的脂肪分解。
