Kamil D, Tepelmann J, Berg C, Heep A, Axt-Fliedner R, Gembruch U, Geipel A
Department of Obstetrics and Prenatal Medicine, University of Bonn, Bonn, Germany.
Ultrasound Obstet Gynecol. 2008 Mar;31(3):296-302. doi: 10.1002/uog.5260.
To describe the spectrum of prenatally diagnosed fetal tumors, and the course and fetal outcome in affected pregnancies.
This was a retrospective study in two German tertiary referral centers of 84 fetuses with tumors diagnosed in the prenatal period. The tumors were classified according to their location and histology.
The most common site of origin was the heart (20/84, 23.8%), followed by the face and neck region (19/84, 22.6%) and the abdomen (16/84, 19%). Lymphangiomas (21/84, 25%) and rhabdomyomas (19/84, 22.6%) comprised half of the tumor histology. Less frequently, teratomas (14/84, 16.6%) and hemangiomas (12/84, 14.2%) were seen. Complications included arrhythmia in cases with rhabdomyoma (8/19, 42%) and signs of heart failure in cases with hemangioma (4/12, 33%) and teratoma (4/14, 28.6%). The overall survival rate was 75%. Cases with either a histological diagnosis of teratoma or tumor located in the brain had the worst prognosis.
The combination of sonographic features and their location allows reliable prediction of the histological type in the vast majority of fetal tumors. Malignancy, associated malformations and aneuploidy are observed infrequently. Knowledge of the presence of a fetal tumor facilitates close surveillance by a specialized team, which might lead to early recognition of problems and improve perinatal outcome.
描述产前诊断的胎儿肿瘤谱，以及受影响妊娠的病程和胎儿结局。
这是一项在德国两家三级转诊中心进行的回顾性研究，纳入了84例产前诊断为肿瘤的胎儿。根据肿瘤的位置和组织学进行分类。
最常见的起源部位是心脏（20/84，23.8%），其次是面部和颈部区域（19/84，22.6%）以及腹部（16/84，19%）。淋巴管瘤（21/84，25%）和横纹肌瘤（19/84，22.6%）占肿瘤组织学类型的一半。较少见的是畸胎瘤（14/84，16.6%）和血管瘤（12/84，14.2%）。并发症包括横纹肌瘤病例中的心律失常（8/19，42%）、血管瘤病例中的心力衰竭体征（4/12，33%）和畸胎瘤病例中的心力衰竭体征（4/14，28.6%）。总体生存率为75%。组织学诊断为畸胎瘤或肿瘤位于脑部的病例预后最差。
超声特征及其位置的组合能够在绝大多数胎儿肿瘤中可靠地预测组织学类型。恶性肿瘤、相关畸形和非整倍体很少见。了解胎儿肿瘤的存在有助于专业团队进行密切监测，这可能会导致问题的早期识别并改善围产期结局。
