Robinson A
Hope Hospital, Salford Royal Hospitals Foundation Trust, Salford, UK.
Aliment Pharmacol Ther. 2008 Mar;27 Suppl 1:9-14. doi: 10.1111/j.1365-2036.2008.03604.x.
Adherence to medications in inflammatory bowel disease is associated with a reduced risk of both relapse and colorectal cancer development in the long term. However, many patients are non-adherent to their prescribed treatment regimen.
To review and discuss the extent of medication non-adherence in inflammatory bowel disease patients, the predictors of non-adherence, and strategies for optimizing patient adherence.
More than 40% of inflammatory bowel disease patients do not adhere to their medication and thus a significant number of patients are not receiving the full benefits from their treatment - that is, remission and disease maintenance. The causes of medication non-adherence are multi-factorial. Improving medication adherence in patients is an important challenge for physicians; understanding the different patient types, the reasons given by patients for non-adherence and the predictors of non-adherence will help devise suitable plans to optimize patient adherence. Approaches such as improving the physician-patient relationship, individualized therapy, providing patient information and support, self-management programmes and practical aide memoires can be beneficial.
Implementation of strategies to improve medication adherence in inflammatory bowel disease patients increases the likelihood of patients achieving disease remission and maintaining remission in the long term, thereby improving symptom control and quality of life.
炎症性肠病患者坚持服药与长期降低复发风险和结直肠癌发生风险相关。然而，许多患者不坚持其规定的治疗方案。
回顾并讨论炎症性肠病患者药物治疗不依从的程度、不依从的预测因素以及优化患者依从性的策略。
超过40%的炎症性肠病患者不坚持服药，因此大量患者未从治疗中获得全部益处，即缓解和疾病维持。药物治疗不依从的原因是多方面的。提高患者的药物依从性对医生来说是一项重要挑战；了解不同类型的患者、患者不依从的原因以及不依从的预测因素将有助于制定合适的计划以优化患者依从性。诸如改善医患关系、个体化治疗、提供患者信息和支持、自我管理计划以及实用的备忘单等方法可能会有所帮助。
实施提高炎症性肠病患者药物依从性的策略可增加患者实现疾病缓解并长期维持缓解的可能性，从而改善症状控制和生活质量。
