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儿童肾移植的长期预后:中国单中心经验

The long-term outcomes of pediatric kidney transplantation: a single-centre experience in China.

作者信息

Wu Zhi-Xian, Yang Shun-Liang, Wu Wei-Zhen, Cai Jin-Quan, Wang Qing-Hua, Wang Dong, Gao Xia, Liao Lian-Ming, Tan Jian-Ming

机构信息

Transplant Center, General Hospital, Fuzhou, Fujian Province, China.

出版信息

Pediatr Transplant. 2008 Mar;12(2):215-8. doi: 10.1111/j.1399-3046.2007.00814.x.

Abstract

To explore the long-term outcomes of paediatric kidney transplantation and the effects of renal allograft on growth, education, employment, marriage and procreation. Twenty-seven children with ESRD received the renal allograft from 1985 to 2001. The patient and kidney survival rate, renal function, growth and employment, etc., were reviewed retrospectively. The average follow-up period was 10.3 +/- 4.4 yr. The one-, three-, five- and 10-yr graft survival rates were 96.3%, 88.9%, 81.5% and 66.7%, respectively, and the corresponding patient survival rates were 100%, 92.6%, 85.2% and 68.8%. The body weight gain was 4-10 kg in one-yr post-operative and the height increased 0-2 cm for girls and 2-5 cm for boys. A total of 44.4% of the recipients accomplished their education above junior high school. The employment rate was 46.2% in males, and 57.2% in females. Twelve patients were married. Non-adherence occurred in 30% of the recipients. Forty percent of the surviving recipients developed complications. Seven patients died. More attention should be paid to non-adherence of medications and more supports from the society are required to improve the life quality of paediatric recipients, especially in employment and education.

摘要

探讨小儿肾移植的长期预后以及同种异体肾移植对生长、教育、就业、婚姻和生育的影响。1985年至2001年,27例终末期肾病患儿接受了同种异体肾移植。回顾性分析患者及肾脏存活率、肾功能、生长发育及就业情况等。平均随访时间为10.3±4.4年。1年、3年、5年和10年的移植肾存活率分别为96.3%、88.9%、81.5%和66.7%,相应的患者存活率分别为100%、92.6%、85.2%和68.8%。术后1年体重增加4 - 10kg,女孩身高增加0 - 2cm,男孩身高增加2 - 5cm。共有44.4%的受者完成了初中以上教育。男性就业率为46.2%,女性为57.2%。12例患者结婚。30%的受者出现不依从情况。40%的存活受者发生并发症。7例患者死亡。应更加关注药物治疗的不依从性,社会需要提供更多支持以提高小儿肾移植受者的生活质量,尤其是在就业和教育方面。

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