Fanelli Francesca, Dell'orco Daniele
Dulbecco Telethon Institute and Department of Chemistry, via Campi 183, 41100 Modena, Italy.
FEBS Lett. 2008 Mar 19;582(6):991-6. doi: 10.1016/j.febslet.2008.02.041. Epub 2008 Feb 26.
The structure of the photoactivated deprotonated rhodopsin intermediate was compared with two different structures of dark rhodopsin. Structure comparisons relied on the computation of molecular indices and on docking simulations with heterotrimeric transducin (Gt). The results of this study provide the first evidence that dark and photoactivated rhodopsins share a common recognition mode to Gt, characterized by the docking of the Gt alpha C-tail in the proximity to the E/DRY motif of rhodopsin.
将光激活的去质子化视紫红质中间体的结构与暗视紫红质的两种不同结构进行了比较。结构比较依赖于分子指标的计算以及与异源三聚体转导蛋白（Gt）的对接模拟。这项研究的结果提供了首个证据，即暗视紫红质和光激活视紫红质对Gt具有共同的识别模式，其特征是Gtα亚基的C末端尾巴对接在视紫红质的E/DRY基序附近。
