99mTc EC膜联蛋白V的成像与剂量测定：针对乳腺肿瘤细胞凋亡的初步临床研究
Imaging and dosimetry of 99mTc EC annexin V: preliminary clinical study targeting apoptosis in breast tumors.
作者信息
Kurihara Hiroaki, Yang David J, Cristofanilli Massimo, Erwin William D, Yu Dong-Fang, Kohanim Saady, Mendez Richard, Kim E Edmund
机构信息
Department of Experimental Diagnostic Imaging, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.
出版信息
Appl Radiat Isot. 2008 Sep;66(9):1175-82. doi: 10.1016/j.apradiso.2008.01.012. Epub 2008 Jan 26.
Abstract
BACKGROUND
Early detection of cellular events is important to predict the outcome of the patients. This study was aimed to use (99m)Tc EC-annexin V to image tumor cells undergoing apoptosis.
METHODS
In 10 patients with breast cancer, scintigraphic images and dosimetric estimates were obtained after administering (99m)Tc EC-annexin V.
RESULTS
Nine of the 10 cases showed detectable (99m)Tc EC-annexin V uptake in tumor. Higher values of T/N ratios are associated with patient after treatment.
CONCLUSIONS
Apoptosis can be quantified using (99m)Tc EC-annexin V.
摘要
背景
早期检测细胞事件对于预测患者的预后很重要。本研究旨在使用（99m）锝标记的依 Annexin V 来对发生凋亡的肿瘤细胞进行成像。
方法
对 10 例乳腺癌患者给予（99m）锝标记的依 Annexin V 后，获取闪烁扫描图像和剂量学估计值。
结果
10 例患者中有 9 例在肿瘤中显示出可检测到的（99m）锝标记的依 Annexin V 摄取。较高的 T/N 比值与治疗后的患者相关。
结论
可以使用（99m）锝标记的依 Annexin V 对凋亡进行定量。
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2
The effect on tumor response of adding sequential preoperative docetaxel to preoperative doxorubicin and cyclophosphamide: preliminary results from National Surgical Adjuvant Breast and Bowel Project Protocol B-27.
J Clin Oncol. 2003 Nov 15;21(22):4165-74. doi: 10.1200/JCO.2003.12.005. Epub 2003 Oct 14.
3
Neoadjuvant chemotherapy for breast carcinoma: multidisciplinary considerations of benefits and risks.
Cancer. 2003 Sep 15;98(6):1150-60. doi: 10.1002/cncr.11603.
4
Early changes in apoptosis and proliferation following primary chemotherapy for breast cancer.
Br J Cancer. 2003 Sep 15;89(6):1035-41. doi: 10.1038/sj.bjc.6601173.
5
6
Expression of caspase-3 and -7 does not correlate with the extent of apoptosis in primary breast carcinomas.
Cell Cycle. 2002 Sep-Oct;1(5):337-42.
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J Exp Clin Cancer Res. 2002 Jun;21(2):233-8.
8
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