Laboratory of Tissue Regeneration and Immunology and Department of Periodontics, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, School of Stomatology, Capital Medical University, Beijing 100050, China.
Department of Biochemistry and Molecular Biology, Nihon University School of Dentistry at Matsudo, Chiba 271-8587, Japan.
Int J Mol Sci. 2022 Jul 26;23(15):8202. doi: 10.3390/ijms23158202.
Apoptosis plays an important role in development and in the maintenance of homeostasis. Apoptotic bodies (ApoBDs) are specifically generated from apoptotic cells and can contain a large variety of biological molecules, which are of great significance in intercellular communications and the regulation of phagocytes. Emerging evidence in recent years has shown that ApoBDs are essential for maintaining homeostasis, including systemic bone density and immune regulation as well as tissue regeneration. Moreover, studies have revealed the therapeutic effects of ApoBDs on systemic diseases, including cancer, atherosclerosis, diabetes, hepatic fibrosis, and wound healing, which can be used to treat potential targets. This review summarizes current research on the generation, application, and reconstruction of ApoBDs regarding their functions in cellular regulation and on systemic diseases, providing strong evidence and therapeutic strategies for further insights into related diseases.
细胞凋亡在发育和维持内稳态中起着重要作用。凋亡小体（ApoBDs）是由凋亡细胞特异性产生的，可以包含大量的生物分子，这些分子在细胞间通讯和吞噬细胞的调节中具有重要意义。近年来的新证据表明，ApoBDs 对于维持内稳态至关重要，包括全身骨密度和免疫调节以及组织再生。此外，研究还揭示了 ApoBDs 在全身性疾病（包括癌症、动脉粥样硬化、糖尿病、肝纤维化和伤口愈合）中的治疗作用，可用于治疗潜在靶点。本综述总结了关于 ApoBDs 在细胞调节和全身性疾病中的生成、应用和重建的研究现状，为进一步深入了解相关疾病提供了有力的证据和治疗策略。
