Theilen Brenda M, Gritzke Kevin A, Knutsen P Gaye, Riek Amy E, McGill Janet B, Sicard Gregory A, Tobin Garry S
Department of Surgery, Washington University School of Medicine, St. Louis, Missouri, USA.
Endocr Pract. 2008 Mar;14(2):185-91. doi: 10.4158/EP.14.2.185.
To describe a structured inpatient insulin management protocol and order set for glycemic control on a vascular surgery service.
Patients admitted to the vascular surgery service with underlying diabetes were enrolled in a study of use of a preprinted basal-bolus insulin order set based on a total daily dose of 0.5 U/kg (0.25 U/kg of insulin glargine and 0.25 U/kg of insulin as part divided into 3 equal mealtime doses). Outcomes included the mean glycemic control at each of 5 established time intervals, the percentage of blood glucose measurements within the target range of 70 to 180 mg/dL, the incidence of hypoglycemia, and the insulin dosages. Historical control patients with diabetes from the same hospital service were used for comparison.
Both the study group and the control group consisted of 26 patients. The number of finger-stick blood glucose measurements performed was 871 in the control group and 896 in the intervention group. The mean blood glucose level (+/- SD) for the intervention group was 149.4 +/- 50.7 mg/dL, in comparison with 165.2 +/- 64.4 mg/dL for the control group. The incidence of hypoglycemia decreased 50% in the intervention group-from 32 (4% of the finger-stick assessments in the control group) to 19 (2% of the finger-stick blood glucose measurements in the study group). The blood glucose target range of 70 to 180 mg/dL was achieved in 75% of the measurements in the study group versus 61% in the control group. The basal insulin dose was unchanged in 65% of the patients, and of the 9 patients requiring a change in the dose, 5 had the dose decreased by 10% and 4 had the dose increased by 10%.
The use of a standardized basal-bolus weight-based insulin regimen was successful at achieving improved glycemic control as well as reducing the incidence of hypoglycemia in an inpatient population with diabetes.
