Weikert Blair C, Blumberg Emily A
Hospital of the University of Pennsylvania, Division of Infectious Diseases, 3400 Spruce Street, 3 Silverstein, Suite E, Philadelphia, PA 19104, USA.
Clin J Am Soc Nephrol. 2008 Mar;3 Suppl 2(Suppl 2):S76-86. doi: 10.2215/CJN.02900707.
Viral infections remain a significant cause of morbidity and mortality following renal transplantation. Although cytomegalovirus is the most common opportunistic pathogen seen in transplant recipients, numerous other viruses have also affected outcomes. In some cases, preventive measures such as pretransplant screening, prophylactic antiviral therapy, or post transplant viral monitoring may limit the impact of these infections. Recent advances in laboratory monitoring and antiviral therapy have improved outcomes. This review will summarize the major viral infections seen following transplant and discuss strategies for prevention and management of these potential pathogens.
病毒感染仍然是肾移植后发病和死亡的重要原因。虽然巨细胞病毒是移植受者中最常见的机会性病原体,但许多其他病毒也会影响移植结果。在某些情况下,诸如移植前筛查、预防性抗病毒治疗或移植后病毒监测等预防措施可能会限制这些感染的影响。实验室监测和抗病毒治疗的最新进展改善了治疗结果。本综述将总结移植后出现的主要病毒感染,并讨论预防和管理这些潜在病原体的策略。