Ison Michael G
Division of Infectious Diseases, Transplant Infectious Diseases Service, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Clin Infect Dis. 2006 Aug 1;43(3):331-9. doi: 10.1086/505498. Epub 2006 Jun 19.
Adenoviruses are increasingly recognized as contributors to morbidity and mortality among stem cell and solid-organ transplant recipients. Clinical presentations range from asymptomatic viremia to respiratory and gastrointestinal disease, hemorrhagic cystitis, and severe disseminated illness. The limited clinical data available support the use of cidofovir for many of these illnesses. Prospective studies are needed to better understand the pathogenesis of and therapeutic options for adenoviral infections in this patient population.
腺病毒越来越被认为是导致干细胞和实体器官移植受者发病和死亡的因素。临床表现从无症状病毒血症到呼吸道和胃肠道疾病、出血性膀胱炎以及严重的播散性疾病不等。现有的有限临床数据支持使用西多福韦治疗其中许多疾病。需要进行前瞻性研究，以更好地了解该患者群体腺病毒感染的发病机制和治疗选择。
