Dohm C P, Kermer P, Bähr M
Department of Neurology, University Hospital Gottingen, Gottingen, Germany.
Neurodegener Dis. 2008;5(6):321-38. doi: 10.1159/000119459. Epub 2008 Feb 29.
Many neurodegenerative diseases such as Parkinson's, Alzheimer's, Huntington's and Lou Gehrig's disease are associated with the misfolding and aggregation of proteins. While the relevance of these aggregates for neuronal degeneration and their impact on cellular function is still a matter of debate, several experimental therapeutic approaches have been aimed at interfering with protein aggregation. In this review, we want to summarize the current understanding of aggregate formation and toxicity in neurodegenerative diseases with an emphasis on Parkinson's disease. Furthermore, we will discuss current treatment strategies in these diseases targeting aggregate formation and concurrent neuronal cell death in these diseases.
许多神经退行性疾病，如帕金森病、阿尔茨海默病、亨廷顿舞蹈症和肌萎缩侧索硬化症，都与蛋白质的错误折叠和聚集有关。尽管这些聚集体与神经元变性的相关性及其对细胞功能的影响仍存在争议，但已有几种实验性治疗方法旨在干扰蛋白质聚集。在这篇综述中，我们想总结目前对神经退行性疾病中聚集体形成和毒性的理解，重点是帕金森病。此外，我们将讨论针对这些疾病中聚集体形成和并发神经元细胞死亡的当前治疗策略。
