Department of Developmental and Molecular Biology, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
Mov Disord. 2010;25 Suppl 1:S49-54. doi: 10.1002/mds.22718.
The cellular surveillance systems guarantee proper removal of altered components from inside cells. Alterations of these systems in neurons have been proposed to be involved in the pathogenesis of different neurodegenerative disorders. In this review, we comment on the advances in our current understanding of how changes in the intracellular proteolytic systems, the main components of the cellular quality control system, contribute to neurodegeneration, with special emphasis on Parkinson's disease.
细胞监控系统可确保从细胞内部适当清除异常成分。有研究提出，神经元中这些系统的改变可能与多种神经退行性疾病的发病机制有关。本文对细胞质量控制系统主要组成部分——细胞内蛋白水解系统改变导致神经退行性变的机制的最新研究进展进行综述，重点探讨帕金森病的相关内容。
