Gudasi Kalagouda B, Havanur Vidyadhar C, Patil Siddappa A, Patil Basavaraj R
Department of Chemistry, Karnatak University, Dharwad 580 003, India.
Met Based Drugs. 2007;2007:37348. doi: 10.1155/2007/37348.
New lanthanide(III) complexes with 2-[2-hydroxy-3-methoxyphenyl]-3-[hydroxyl-3-methoxybenzylamino]-1,2-dihydroquin- azoline-4(3H)-one (Hmpbaq) have been synthesized and characterized by elemental analysis, conductance measurements, magnetic susceptibilities, spectroscopic (IR, NMR, UV, EPR), and thermal studies. Molar conductance studies indicate 1 : 1 electrolytic behavior for these complexes. IR spectra indicate that Hmpbaq acts as a tridentate ligand coordinating through carbonyl oxygen, benzyl amine nitrogen, and deprotonated phenolic oxygen. TG and DTA studies of La(III) and Pr(III) complexes indicate the presence of two coordinated water molecules. Based on these studies, the complexes have been formulated as [La(mpbaq)(2)(H(2)O)(2)].NO(3), where Ln = La(III), Pr(III), Nd(III), Sm(III), Eu(III), Gd(III), Th(III), Dy(III), and Y(III). The ligand, lanthanide(III) salts, and the corresponding complexes have been simultaneously screened for their antibacterial and antifungal activities and compared with the drugs in use.
合成了新型镧系元素（III）与2-[2-羟基-3-甲氧基苯基]-3-[羟基-3-甲氧基苄基氨基]-1,2-二氢喹唑啉-4(3H)-酮（Hmpbaq）的配合物，并通过元素分析、电导率测量、磁化率、光谱学（红外、核磁共振、紫外、电子顺磁共振）和热分析进行了表征。摩尔电导率研究表明这些配合物具有1 : 1的电解行为。红外光谱表明Hmpbaq作为三齿配体，通过羰基氧、苄胺氮和去质子化的酚氧进行配位。对镧（III）和镨（III）配合物的热重和差热分析研究表明存在两个配位水分子。基于这些研究，配合物被拟定为[La(mpbaq)(2)(H(2)O)(2)].NO(3)，其中Ln = La(III)、Pr(III)、Nd(III)、Sm(III)、Eu(III)、Gd(III)、Th(III)、Dy(III)和Y(III)。对配体、镧系元素（III）盐以及相应的配合物同时进行了抗菌和抗真菌活性筛选，并与正在使用的药物进行了比较。
