Mohanty Keshar K, Gupta Manisha, Girdhar B K, Girdhar A, Chakma J K, Sengupta U
National JALMA Institute for Leprosy and Other Mycobacterial Diseases, Taj Ganj, Agra 282 001, India.
Lepr Rev. 2007 Dec;78(4):386-90.
To assess the urinary nitric oxide metabolites in lepromatous patients in ENL (type 2 reactions) and to compare these metabolites after subsidence of reactions following antireactional therapy. Further to compare the levels in a group of lepromatous leprosy patients without reactions.
The initial urine samples were collected from lepromatous leprosy patients when they came with ENL before commencing antireactional therapy and repeat samples were taken after resolution of ENL. Morning urine samples were collected from LL patients without reactions. Nitrites and nitrates in urine were measured using commercially available kit. Mean levels of nitric oxide metabolites of LL patients with ENL and without ENL were compared by student's 't' test. The level during ENL and after resolution was compared by paired 't' test.
The nitric oxide metabolites were analyzed in 14 LL patients with ENL and after resolution of ENL and in 5 LL patients without reaction. The level of urinary nitric oxide metabolite is higher in LL patients in ENL reaction compared to LL patients without reaction (P < 0.04). These levels were reduced significantly with resolution of reaction following antireactional therapy (P < 0.004).
The findings of this study suggested that the NO/NOM excretion is increased in leprosy patients during ENL episodes. With antireactional therapy (steroids) and clinical improvement the levels are reduced.
评估瘤型麻风患者在结节性红斑（2型反应）中的尿一氧化氮代谢产物，并在抗反应治疗后反应消退时比较这些代谢产物。进一步比较一组无反应的瘤型麻风患者的水平。
最初的尿液样本是在瘤型麻风患者出现结节性红斑且尚未开始抗反应治疗时采集的，在结节性红斑消退后采集重复样本。从无反应的瘤型麻风患者中采集晨尿样本。使用市售试剂盒测量尿液中的亚硝酸盐和硝酸盐。通过学生t检验比较有结节性红斑和无结节性红斑的瘤型麻风患者一氧化氮代谢产物的平均水平。通过配对t检验比较结节性红斑期间和消退后的水平。
对14例有结节性红斑及结节性红斑消退后的瘤型麻风患者和5例无反应的瘤型麻风患者的一氧化氮代谢产物进行了分析。与无反应的瘤型麻风患者相比，有结节性红斑反应的瘤型麻风患者尿一氧化氮代谢产物水平更高（P < 0.04）。抗反应治疗后随着反应消退，这些水平显著降低（P < 0.004）。
本研究结果表明，在结节性红斑发作期间，麻风患者的NO/NOM排泄增加。随着抗反应治疗（类固醇）和临床改善，水平降低。
