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[糖尿病的趋势]

[Trends in diabetes].

作者信息

Ruiz J, Egli M

机构信息

Service d'endocrinologie, diabétologie et métabolisme, CHUV, 1011 Lausanne.

出版信息

Rev Med Suisse. 2008 Jan 16;4(140):116, 118-21.

Abstract

A recent meta-analysis on the rosiglitazone in the treatment of type 2 diabetes revealed a significant increased risk of myocardial infarction and a trend to a higher cardiovascular mortality. In the following month after this publication, the methodology as its conclusions were criticized. This study shows the limits of the meta-analyses to which one lends a row obviously too high in the hierarchy of the levels of evidence. The study 4T evaluated 3 insulin strategies in the treatment of the type 2 diabetes. The results at one year show that only a minority of the patients achieve the goals. Post-Steno 2 was presented at the European congress diabetes. These new data confirm that the intensified treatment of all cardiovascular factors risk allows a major reduction of cardiovascular mortality after 13.3 years.

摘要

最近一项关于罗格列酮治疗2型糖尿病的荟萃分析显示,心肌梗死风险显著增加,且有心血管死亡率升高的趋势。在该研究发表后的接下来一个月,其方法和结论受到了批评。这项研究显示了荟萃分析的局限性,显然在证据水平层次中给予其的权重过高。4T研究评估了3种胰岛素治疗策略用于治疗2型糖尿病。一年的结果表明,只有少数患者达到目标。“Post-Steno 2”在欧洲糖尿病大会上公布。这些新数据证实,强化治疗所有心血管危险因素可使13.3年后心血管死亡率大幅降低。

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