Nash D R, Kaplan S M, Norman A B, Sanberg P R
Department of Psychiatry, University of Cincinnati College of Medicine, Ohio 45267-0559.
J Neural Transplant Plast. 1991;2(1):75-9. doi: 10.1155/NP.1991.75.
The present study examined the recent report that transplantation of neonatal striatal tissue into kainic acid (KA) lesioned striatum protected the contralateral striatum from a subsequent KA lesion. We did not find a significant difference in the survival rate of animals that received neonatal striatal transplants into a KA lesioned striatum followed by a subsequent lesion of the contralateral striatum compared to those animals that received bilateral KA-induced striatal lesions alone. The tissue transplants did not protect against the degeneration of striatal neurons induced by KA. Indeed, the survival rate was very low (25%) in the transplant groups. A second experiment was also performed to examine whether a neonatal striatal transplant might reduce the severe syndrome of aphagia and adipsia associated with KA lesions of the striatum. Animals that received the neonatal striatal transplants showed increased aphagia and adipsia compared to animals only receiving the KA lesion. Again, the transplant group had a very low survival rate (10%). The present study was unable to confirm that neonatal striatal transplants protect against KA lesions either by themselves or in conjunction with a recent KA lesion.
本研究考察了最近的一份报告，该报告称将新生纹状体组织移植到经 kainic 酸（KA）损伤的纹状体中，可保护对侧纹状体免受随后 KA 损伤的影响。我们发现，与仅接受双侧 KA 诱导的纹状体损伤的动物相比，将新生纹状体移植到 KA 损伤的纹状体中，随后对侧纹状体再受损伤的动物，其存活率并无显著差异。组织移植并不能防止 KA 诱导的纹状体神经元变性。实际上，移植组的存活率非常低（25%）。还进行了第二项实验，以考察新生纹状体移植是否可能减轻与纹状体 KA 损伤相关的严重摄食和饮水障碍综合征。与仅接受 KA 损伤的动物相比，接受新生纹状体移植的动物出现了更严重的摄食和饮水障碍。同样，移植组的存活率非常低（10%）。本研究无法证实新生纹状体移植本身或与近期 KA 损伤联合起来能保护免受 KA 损伤。
