Kaida Hayato, Ishibashi Masatoshi, Fujii Teruhiko, Kurata Seiji, Ogo Etsuyo, Tanaka Maki, Hayabuchi Naofumi
Division of Nuclear Medicine, PET Center and Department of Radiology, Kurume University School of Medicine, 67 Asahi-Machi, Kurume, Fukuoka 830-0011, Japan.
Ann Nucl Med. 2008 Feb;22(2):95-101. doi: 10.1007/s12149-007-0092-1. Epub 2008 Mar 3.
The aim of this study was to investigate the detection rate of breast cancer by positron emission tomography cancer screening using a breast positioning device.
Between January 2004 and January 2006, 1,498 healthy asymptomatic individuals underwent cancer screening by fluorine-18 fluorodeoxyglucose positron emission tomography (FDG-PET) at our institution; 660 of 1498 asymptomatic healthy women underwent breast PET imaging in the prone position using the breast positioning device to examine the mammary glands in addition to whole-body PET imaging. All subjects that showed abnormal (18)F-FDG uptake in the mammary glands were referred for further examination or surgery at our institution or a local hospital. Our data were compared with the histopathological findings or findings of other imaging modalities in our institution and replies from the doctors at another hospital.
Of the 660 participants, 7 (1.06%) were found to have breast cancers at a curable stage. All the seven cancers were detected by breast PET imaging, but only five of these were detected by whole-body PET imaging; the other two were detected by breast PET imaging using the breast positioning device.
In cancer screening, prone breast imaging using a positioning device may help to improve the detection rate of breast cancer. However, overall cancer including mammography and ultrasonography screening should be performed to investigate the false-negative cases and reduce false-positive cases. The effectiveness of prone breast PET imaging in cancer screening should be investigated using a much larger number of cases in the near future.
本研究旨在探讨使用乳腺定位装置的正电子发射断层扫描癌症筛查对乳腺癌的检出率。
2004年1月至2006年1月期间，1498名健康无症状个体在本机构接受了氟-18氟脱氧葡萄糖正电子发射断层扫描（FDG-PET）癌症筛查；1498名无症状健康女性中的660名在俯卧位使用乳腺定位装置进行了乳腺PET成像，除全身PET成像外还对乳腺进行了检查。所有乳腺中显示异常（18）F-FDG摄取的受试者均被转介至本机构或当地医院进行进一步检查或手术。我们的数据与本机构的组织病理学结果或其他成像方式的结果以及另一家医院医生的回复进行了比较。
在660名参与者中，发现7例（1.06%）处于可治愈阶段的乳腺癌。所有这7例癌症均通过乳腺PET成像检测到，但其中只有5例通过全身PET成像检测到；另外2例通过使用乳腺定位装置的乳腺PET成像检测到。
在癌症筛查中，使用定位装置进行俯卧位乳腺成像可能有助于提高乳腺癌的检出率。然而，应进行包括乳房X线摄影和超声检查在内的全面癌症筛查，以调查假阴性病例并减少假阳性病例。俯卧位乳腺PET成像在癌症筛查中的有效性应在不久的将来使用更多病例进行研究。
