Hansen Michael K, Connolly Thomas M
Wyeth Research, Discovery Translational Medicine, 500 Arcola Rd, Collegeville, PA 19426, USA.
Curr Opin Investig Drugs. 2008 Mar;9(3):247-55.
Nuclear hormone receptors, including peroxisome proliferator-activated receptors (PPARs), liver X receptors (LXRs), and the farnesoid X receptor (FXR), are transcription factors involved in the regulation of essential metabolic functions, including glucose and lipid metabolism, reverse cholesterol transport, and the regulation of bile acids. This review summarizes new developments in the use of PPAR, LXR and FXR agonists for the treatment of obesity and cardiovascular diseases, including dyslipidemia and atherosclerosis. Currently available drugs and future areas of research for new therapies are also discussed.
核激素受体，包括过氧化物酶体增殖物激活受体（PPARs）、肝脏X受体（LXRs）和法尼醇X受体（FXR），是参与调节基本代谢功能的转录因子，这些功能包括葡萄糖和脂质代谢、逆向胆固醇转运以及胆汁酸调节。本综述总结了使用PPAR、LXR和FXR激动剂治疗肥胖症和心血管疾病（包括血脂异常和动脉粥样硬化）的新进展。还讨论了目前可用的药物以及新疗法未来的研究领域。
