State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214126, China.
School of Food Science and Technology, Jiangnan University, Wuxi 214126, China.
Nutrients. 2023 Apr 18;15(8):1952. doi: 10.3390/nu15081952.
This study aimed to investigate the dose-response effect of CCFM683 on relieving psoriasis and its underlying patterns. Specifically, the expression of keratin 16, keratin 17, and involucrin were substantially decreased by administration of 10 CFU and 10 CFU per day. Moreover, interleukin (IL)-17 and TNF-α levels were substantially decreased by 10 and 10 CFU/day. Furthermore, the gut microbiota in mice treated with 10 or 10 CFU/day was rebalanced by improving the diversity, regulating microbe interactions, increasing , and decreasing . Moreover, the concentrations of colonic bile acids were positively correlated with the effectiveness of the strain in relieving psoriasis. The gavage dose should be more than 10 CFU/day to improve psoriasis according to the dose-effect curve. In conclusion, CCFM683 supplementation alleviated psoriasis in a dose-dependent manner by recovering microbiota, promoting bile acid production, regulating the FXR/NF-κB pathway, diminishing proinflammatory cytokines, regulating keratinocytes, and maintaining the epidermal barrier function. These results may help guide probiotic product development and clinical trials in psoriasis.
本研究旨在探讨 CCFM683 缓解银屑病及其潜在机制的剂量反应效应。具体而言，每天给予 10 CFU 和 10 CFU 的 CCFM683 可显著降低角蛋白 16、角蛋白 17 和内披蛋白的表达。此外，每天给予 10 CFU 和 10 CFU 的 CCFM683 可显著降低白细胞介素（IL）-17 和肿瘤坏死因子（TNF）-α的水平。此外，通过增加 、减少 和改善多样性、调节微生物相互作用，每天给予 10 或 10 CFU 的 CCFM683 可使小鼠的肠道微生物群重新平衡。此外，结肠胆汁酸的浓度与该菌株缓解银屑病的有效性呈正相关。根据剂量效应曲线，灌胃剂量应大于 10 CFU/天，以改善银屑病。总之，CCFM683 通过恢复微生物群、促进胆汁酸生成、调节 FXR/NF-κB 通路、减少促炎细胞因子、调节角质形成细胞和维持表皮屏障功能，以剂量依赖的方式缓解银屑病。这些结果可能有助于指导益生菌产品的开发和银屑病的临床试验。
