Kruger E Freya, Puchalski Sarah M, Pollard Rachel E, Galuppo Larry D, Hornof William J, Wisner Erik R
Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis, CA 95616, USA.
Am J Vet Res. 2008 Mar;69(3):371-7. doi: 10.2460/ajvr.69.3.371.
To define the reference range for laminar blood flow (BF) and vascular permeability (VPM) in horses without laminitis by use of dynamic contrast-enhanced computed tomography (CT).
9 adult horses that were not lame and had no abnormalities of the laminae or phalanges detectable via radiographic examination.
Each horse was anesthetized by use of a routine protocol. Horses were placed in right or left lateral recumbency with the dependent forelimb in the CT gantry; only 1 limb of each horse was scanned. Serial 10-mm collimated transverse CT images were acquired at the same location every other second for 90 seconds during infusion of ionic, iodinated contrast medium. Custom software was used to estimate BF, VPM, and fractional vascular volume (FVV) in the dorsal, dorsomedial, and dorsolateral laminar regions.
Among the 9 horses' forelimbs, mean +/- SD dorsal laminar BF was 0.43 +/- 0.21 mL*min(1)mL(1). Mean dorsomedial and dorsolateral laminar BFs were 0.26 +/- 0.16 mLmin(1)mL(1) and 0.24 +/- 0.16 mLmin(1)mL(1), respectively. Mean dorsal laminar VPM was 0.09 +/- 0.03 mLmin(1)mL(1). Mean dorsomedial and dorsolateral laminar VPMs were 0.16 +/- 0.06 mLmin(1)mL(1) and 0.12 +/- 0.06 mLmin(1)*mL(1), respectively. Mean dorsal laminar FVV was 0.63 +/- 0.20 and dorsomedial and dorsolateral laminar FVV were 0.37 +/- 0.14 and 0.34 +/- 0.17, respectively.
In horses, laminar BF, VPM, and FVV can be non-invasively measured by use of dynamic contrast-enhanced CT.
通过使用动态对比增强计算机断层扫描（CT）来确定无蹄叶炎马匹的层流血流（BF）和血管通透性（VPM）的参考范围。
9匹成年马，不跛行，且通过X线检查未发现蹄叶或趾骨有异常。
每匹马按照常规方案进行麻醉。将马置于右侧或左侧卧位，使患侧前肢位于CT扫描架内；每匹马仅扫描1个肢体。在注入离子型碘化造影剂期间，每隔1秒在同一位置采集10毫米准直的连续横向CT图像，共采集90秒。使用定制软件估计背侧、背内侧和背外侧蹄叶区域的BF、VPM和血管分数容积（FVV）。
在9匹马的前肢中，背侧蹄叶BF的平均值±标准差为0.43±0.21毫升·分钟⁻¹·毫升⁻¹。背内侧和背外侧蹄叶BF的平均值分别为0.26±0.16毫升·分钟⁻¹·毫升⁻¹和0.24±0.16毫升·分钟⁻¹·毫升⁻¹。背侧蹄叶VPM的平均值为0.09±0.03毫升·分钟⁻¹·毫升⁻¹。背内侧和背外侧蹄叶VPM的平均值分别为0.16±0.06毫升·分钟⁻¹·毫升⁻¹和0.12±0.06毫升·分钟⁻¹·毫升⁻¹。背侧蹄叶FVV的平均值为0.63±0.20，背内侧和背外侧蹄叶FVV分别为0.37±0.14和0.34±0.17。
在马匹中，可通过动态对比增强CT无创测量蹄叶BF、VPM和FVV。
