使用动态对比增强计算机断层扫描测量马属动物蹄叶血流和血管通透性。

Measurement of equine laminar blood flow and vascular permeability by use of dynamic contrast-enhanced computed tomography.

作者信息

Kruger E Freya, Puchalski Sarah M, Pollard Rachel E, Galuppo Larry D, Hornof William J, Wisner Erik R

机构信息

Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis, CA 95616, USA.

出版信息

Am J Vet Res. 2008 Mar;69(3):371-7. doi: 10.2460/ajvr.69.3.371.

DOI:10.2460/ajvr.69.3.371

PMID:18312136

Abstract

OBJECTIVE

To define the reference range for laminar blood flow (BF) and vascular permeability (VPM) in horses without laminitis by use of dynamic contrast-enhanced computed tomography (CT).

ANIMALS

9 adult horses that were not lame and had no abnormalities of the laminae or phalanges detectable via radiographic examination.

PROCEDURES

Each horse was anesthetized by use of a routine protocol. Horses were placed in right or left lateral recumbency with the dependent forelimb in the CT gantry; only 1 limb of each horse was scanned. Serial 10-mm collimated transverse CT images were acquired at the same location every other second for 90 seconds during infusion of ionic, iodinated contrast medium. Custom software was used to estimate BF, VPM, and fractional vascular volume (FVV) in the dorsal, dorsomedial, and dorsolateral laminar regions.

RESULTS

Among the 9 horses' forelimbs, mean +/- SD dorsal laminar BF was 0.43 +/- 0.21 mL*min(1)mL(1). Mean dorsomedial and dorsolateral laminar BFs were 0.26 +/- 0.16 mLmin(1)mL(1) and 0.24 +/- 0.16 mLmin(1)mL(1), respectively. Mean dorsal laminar VPM was 0.09 +/- 0.03 mLmin(1)mL(1). Mean dorsomedial and dorsolateral laminar VPMs were 0.16 +/- 0.06 mLmin(1)mL(1) and 0.12 +/- 0.06 mLmin(1)*mL(1), respectively. Mean dorsal laminar FVV was 0.63 +/- 0.20 and dorsomedial and dorsolateral laminar FVV were 0.37 +/- 0.14 and 0.34 +/- 0.17, respectively.

CONCLUSIONS AND CLINICAL RELEVANCE

In horses, laminar BF, VPM, and FVV can be non-invasively measured by use of dynamic contrast-enhanced CT.

摘要

目的

通过使用动态对比增强计算机断层扫描（CT）来确定无蹄叶炎马匹的层流血流（BF）和血管通透性（VPM）的参考范围。

动物

9匹成年马，不跛行，且通过X线检查未发现蹄叶或趾骨有异常。

步骤

每匹马按照常规方案进行麻醉。将马置于右侧或左侧卧位，使患侧前肢位于CT扫描架内；每匹马仅扫描1个肢体。在注入离子型碘化造影剂期间，每隔1秒在同一位置采集10毫米准直的连续横向CT图像，共采集90秒。使用定制软件估计背侧、背内侧和背外侧蹄叶区域的BF、VPM和血管分数容积（FVV）。

结果

在9匹马的前肢中，背侧蹄叶BF的平均值±标准差为0.43±0.21毫升·分钟⁻¹·毫升⁻¹。背内侧和背外侧蹄叶BF的平均值分别为0.26±0.16毫升·分钟⁻¹·毫升⁻¹和0.24±0.16毫升·分钟⁻¹·毫升⁻¹。背侧蹄叶VPM的平均值为0.09±0.03毫升·分钟⁻¹·毫升⁻¹。背内侧和背外侧蹄叶VPM的平均值分别为0.16±0.06毫升·分钟⁻¹·毫升⁻¹和0.12±0.06毫升·分钟⁻¹·毫升⁻¹。背侧蹄叶FVV的平均值为0.63±0.20，背内侧和背外侧蹄叶FVV分别为0.37±0.14和0.34±0.17。