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[卡介苗对年轻患者结核病的特异性预防]

[Specific prevention of tuberculosis in young patients by BCG vaccine].

作者信息

Bubochkin B P, Ivanova E S

出版信息

Probl Tuberk. 1991(3):16-9.

PMID:1831262
Abstract

The efficacy of antituberculous BCG revaccination studied in workers, students and young subjects of the penitentiary labour establishments (PLE) was assessed by the level of tuberculin sensitivity, the presence of a postvaccination skin sign, tuberculosis morbidity and severity of a tuberculosis process. The highest efficacy was achieved in workers and students as a result of systematic revaccination. Tuberculosis morbidity in them was 26.2 and 34.5 per 100,000, respectively. In the PLE contingent it was several times higher because they received revaccination as early as their school years. The postvaccination skin signs were found in 91.8% of workers, 76.4% students and 60.5% young subjects of PLE. In students and workers reactions with an infiltrate size of 5-11 mm were predominant and in the PLE contingent those with an infiltrate of 12 mm and more. Subjects having a skin sign had more benign tuberculosis course. Bacillary excretion was found in 48.9% and in those without a skin sign in 72% of cases (p less than 0.05).

摘要

通过结核菌素敏感性水平、接种后皮肤体征的出现情况、结核病发病率以及结核病程的严重程度,对在工人、学生和监狱劳动机构(PLE)的年轻人中进行的抗结核卡介苗复种效果进行了评估。由于进行了系统复种,工人和学生取得了最高的复种效果。他们的结核病发病率分别为每10万人26.2例和34.5例。在PLE人群中,发病率要高出几倍,因为他们早在学生时代就接受了复种。接种后皮肤体征在91.8%的工人、76.4%的学生和60.5%的PLE年轻人中被发现。在学生和工人中,浸润大小为5-11毫米的反应占主导,而在PLE人群中,浸润为12毫米及以上的反应占主导。有皮肤体征的受试者结核病程更良性。48.9%有皮肤体征的病例发现有细菌排泄,而无皮肤体征的病例中这一比例为72%(p<0.05)。

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